publication . Other literature type . Article . 2016

Enantioselective Nickel-Catalyzed anti-Carbometallative Cyclizations of Alkynyl Electrophiles Enabled by Reversible Alkenylnickel E/Z Isomerization

Clarke, Christopher; Incerti-Pradillos, Celia A.; Lam, Hon Wai;
  • Published: 22 Jun 2016
  • Publisher: (:unav)
  • Country: Italy
Abstract
Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species.
Subjects
free text keywords: Colloid and Surface Chemistry, Biochemistry, General Chemistry, Catalysis, Nickel, chemistry.chemical_element, chemistry, Organic chemistry, Electrophile, Isomerization, Enantioselective synthesis, Alkyne, chemistry.chemical_classification, Communication
Related Organizations
Funded by
EC| ETMCECS
Project
ETMCECS
Enantioselective Transition Metal Catalysis for Efficient Chemical Synthesis
  • Funder: European Commission (EC)
  • Project Code: 258580
  • Funding stream: FP7 | SP2 | ERC
,
RCUK| Increasing the Efficiency of Chemical Synthesis Using Asymmetric Transition Metal Catalysis
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/I004769/2
  • Funding stream: EPSRC
,
RCUK| Increasing the Efficiency of Chemical Synthesis Using Asymmetric Transition Metal Catalysis
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/I004769/1
  • Funding stream: EPSRC

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