Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme

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Whitehead, John; Kelly, P. J.; Zhou, Yinghui; Stallard, Nigel; Thygesen, Helene; Bowman, Clive;

Observation of adverse drug reactions during drug development can cause closure of the whole programme. However, if association between the genotype and the risk of an adverse event is discovered, then it might suffice to exclude patients of certain genotypes from futur... View more
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