publication . Article . 2013

The N-terminus of CD14 acts to bind apoptotic cells and confers rapid-tethering capabilities on non-myeloid cells:CD14 and rapid tethering of apoptotic cells

Thomas, Leanne; Bielemeier, Anne; Lambert, Peter A.; Darveau, Richard P.; Marshall, Lindsay J.; Devitt, Andrew;
Open Access English
  • Published: 30 Jul 2013
  • Country: United Kingdom
Abstract
Cell death and removal of cell corpses in a timely manner is a key event in both physiological and pathological situations including tissue homeostasis and the resolution of inflammation. Phagocytic clearance of cells dying by apoptosis is a complex sequential process comprising attraction, recognition, tethering, signalling and ultimately phagocytosis and degradation of cell corpses. A wide range of molecules acting as apoptotic cell-associated ligands, phagocyte-associated receptors or soluble bridging molecules have been implicated within this process. The role of myeloid cell CD14 in mediating apoptotic cell interactions with macrophages has long been known ...
Related Organizations
61 references, page 1 of 5

1. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL et al. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148: 2207-2216. PubMed: 1545126. [OpenAIRE]

2. Brown S, Heinisch I, Ross E, Shaw K, Buckley CD et al. (2002) Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 418: 200-203. doi:10.1038/ nature00811. PubMed: 12110892.

3. Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A et al. (2005) Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123: 321-334. doi:10.1016/j.cell.2005.08.032. PubMed: 16239148. [OpenAIRE]

4. Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M et al. (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFGE8-deficient mice. Science 304: 1147-1150. doi:10.1126/science. 1094359. PubMed: 15155946. [OpenAIRE]

5. Savill JS, Wyllie AH, Henson JE, Walport MJ, Henson PM et al. (1989) Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 83: 865-875. doi:10.1172/JCI113970. PubMed: 2921324. [OpenAIRE]

6. Gregory CD, Pound JD (2010) Microenvironmental influences of apoptosis in vivo and in vitro. Apoptosis 15: 1029-1049. doi:10.1007/ s10495-010-0485-9. PubMed: 20237956. [OpenAIRE]

7. Segundo C, Medina F, Rodríguez C, Martínez-Palencia R, LeyvaCobián F et al. (1999) Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Blood 94: 1012-1020. PubMed: 10419893. [OpenAIRE]

8. Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ et al. (2008) CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood 112: 5026-5036. doi:10.1182/ blood-2008-06-162404. PubMed: 18799722. [OpenAIRE]

9. Peter C, Wesselborg S, Herrmann M, Lauber K (2010) Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells. Apoptosis 15: 1007-1028. doi:10.1007/ s10495-010-0472-1. PubMed: 20157780. [OpenAIRE]

10. Torr EE, Gardner DH, Thomas L, Goodall DM, Bielemeier A et al. (2011) Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells. Cell Death Differ, 19: 671-9. PubMed: 22117198.

11. Gregory CD, Devitt A (2004) The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically? Immunology 113: 1-14. doi:10.1111/j.1365-2567.2004.01959.x. PubMed: 15312130.

12. Fadok VA, Bratton DL, Guthrie L, Henson PM (2001) Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol 166: 6847-6854. PubMed: 11359844. [OpenAIRE]

13. Savill J, Dransfield I, Gregory C, Haslett C (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2: 965-975. doi:10.1038/nri957. PubMed: 12461569.

14. Lauber K, Blumenthal SG, Waibel M, Wesselborg S (2004) Clearance of apoptotic cells: getting rid of the corpses. Mol Cell 14: 277-287. doi: 10.1016/S1097-2765(04)00237-0. PubMed: 15125832.

15. Elliott MR, Ravichandran KS (2010) Clearance of apoptotic cells: implications in health and disease. J Cell Biol 189: 1059-1070. doi: 10.1083/jcb.201004096. PubMed: 20584912. [OpenAIRE]

61 references, page 1 of 5
Related research
Abstract
Cell death and removal of cell corpses in a timely manner is a key event in both physiological and pathological situations including tissue homeostasis and the resolution of inflammation. Phagocytic clearance of cells dying by apoptosis is a complex sequential process comprising attraction, recognition, tethering, signalling and ultimately phagocytosis and degradation of cell corpses. A wide range of molecules acting as apoptotic cell-associated ligands, phagocyte-associated receptors or soluble bridging molecules have been implicated within this process. The role of myeloid cell CD14 in mediating apoptotic cell interactions with macrophages has long been known ...
Related Organizations
61 references, page 1 of 5

1. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL et al. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148: 2207-2216. PubMed: 1545126. [OpenAIRE]

2. Brown S, Heinisch I, Ross E, Shaw K, Buckley CD et al. (2002) Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Nature 418: 200-203. doi:10.1038/ nature00811. PubMed: 12110892.

3. Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A et al. (2005) Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123: 321-334. doi:10.1016/j.cell.2005.08.032. PubMed: 16239148. [OpenAIRE]

4. Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M et al. (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFGE8-deficient mice. Science 304: 1147-1150. doi:10.1126/science. 1094359. PubMed: 15155946. [OpenAIRE]

5. Savill JS, Wyllie AH, Henson JE, Walport MJ, Henson PM et al. (1989) Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 83: 865-875. doi:10.1172/JCI113970. PubMed: 2921324. [OpenAIRE]

6. Gregory CD, Pound JD (2010) Microenvironmental influences of apoptosis in vivo and in vitro. Apoptosis 15: 1029-1049. doi:10.1007/ s10495-010-0485-9. PubMed: 20237956. [OpenAIRE]

7. Segundo C, Medina F, Rodríguez C, Martínez-Palencia R, LeyvaCobián F et al. (1999) Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Blood 94: 1012-1020. PubMed: 10419893. [OpenAIRE]

8. Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ et al. (2008) CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood 112: 5026-5036. doi:10.1182/ blood-2008-06-162404. PubMed: 18799722. [OpenAIRE]

9. Peter C, Wesselborg S, Herrmann M, Lauber K (2010) Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells. Apoptosis 15: 1007-1028. doi:10.1007/ s10495-010-0472-1. PubMed: 20157780. [OpenAIRE]

10. Torr EE, Gardner DH, Thomas L, Goodall DM, Bielemeier A et al. (2011) Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells. Cell Death Differ, 19: 671-9. PubMed: 22117198.

11. Gregory CD, Devitt A (2004) The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically? Immunology 113: 1-14. doi:10.1111/j.1365-2567.2004.01959.x. PubMed: 15312130.

12. Fadok VA, Bratton DL, Guthrie L, Henson PM (2001) Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J Immunol 166: 6847-6854. PubMed: 11359844. [OpenAIRE]

13. Savill J, Dransfield I, Gregory C, Haslett C (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2: 965-975. doi:10.1038/nri957. PubMed: 12461569.

14. Lauber K, Blumenthal SG, Waibel M, Wesselborg S (2004) Clearance of apoptotic cells: getting rid of the corpses. Mol Cell 14: 277-287. doi: 10.1016/S1097-2765(04)00237-0. PubMed: 15125832.

15. Elliott MR, Ravichandran KS (2010) Clearance of apoptotic cells: implications in health and disease. J Cell Biol 189: 1059-1070. doi: 10.1083/jcb.201004096. PubMed: 20584912. [OpenAIRE]

61 references, page 1 of 5
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