Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain

Article English OPEN
Newland, B.; Aied, A.; Pinoncely, A. V.; Zheng, Y.; Zhao, T.; Zhang, H.; Niemeier, R.; Dowd, E.; Pandit, A.; Wang, W.;
(2014)
  • Publisher: Royal Society of Chemistry
  • Identifiers: doi: 10.1039/C3NR06737H
  • Subject:
    mesheuropmc: food and beverages | fungi

The purpose of this study was to develop a platform transfection technology, for applications in the brain, which could transfect astrocytes without requiring cell specific functionalization and without the common cause of toxicity through high charge density. Here we s... View more
  • References (8)

    1. H. Lee, A. K. R. Lytton-Jean, Y. Chen, K. T. Love, A. I. Park, E. D. C. G. Peng, K. Charisse, A. Borodovsky, M. Manoharan, J. S. Donahoe, J. Truelove, M. Nahrendorf, R. Langer and D. G. Anderson, Nature Nanotech., 2012, 7, 389-393.

    2. A. C. Bonoiu, E. J. Bergey, H. Ding, R. Hu, R. Kumar, K.-T. Yong, P. N. Prasad, S. Mahajan, K. E. Picchione, A. Bhattacharjee and T. A. Ignatowski, Nanomedicine, 2011, 6, 617-630.

    3. K. T. Al-Jamal, L. Gherardini, G. Bardi, A. Nunes, C. Guo, C. Bussy, M. A. Herrero, A. Bianco, M. Prato, K. Kostarelos and T. Pizzorusso, Proc. Natl. Acad. Sci. USA, 2011, 108, 10952-10957.

    27. B. Newland, E. Dowd and A. Pandit, Biomaterials Science, 2013, 1, 556-576.

    28. N. Shi, Y. Zhang, C. Zhu, R. J. Boado and W. M. Pardridge, Proc. Natl. Acad. Sci. USA, 2001, 98, 12754-12759.

    29. E. J. Kwon, J. Lasiene, B. E. Jacobson, I.-K. Park, P. J. Horner and S. H. Pun, Biomaterials, 2010, 31, 2417-2424.

    30. J. J. Green, G. T. Zugates, N. C. Tedford, Y. H. Huang, L. G. Griffith, D. A. Lauffenburger, J. A. Sawicki, R. Langer and D. G. Anderson, Adv. Mater., 2007, 19, 2836-2842.

    31. M. Monaghan, U. Greiser, H. Cao, W. Wang and A. Pandit, Drug Deliv. Trans. Res., 2012, 2, 406-414.

  • Metrics
Share - Bookmark