publication . Thesis

The role of nitric oxide and somatic action potentials in a GluR1 independent LTP

Phillips, Keith Geoffrey;
Open Access English
  • Country: United Kingdom
Abstract
Studies in GluRl knockout mice have shown that neocortical LTP consist of both pre- and post-synaptic components that rely on nitric oxide and GluRl respectively (Hardingham and Fox, 2006). Given that GluRl knockout also show hippocampal LTP (Hoffmann et al., 2002) I hypothesised that the residual LTP might depend on nitric oxide. I have found that hippocampal LTP can be induced in GluRl knockout with purely orthodromic stimuli in mature mice (>8weeks) and that a theta-burst protocol was effective at inducing LTP while 100Hz stimulation was not. I found that only theta-burst stimulation produced reliable post-synaptic spikes, while 100Hz stimulation produced rel...
Subjects
Medical Subject Headings: musculoskeletal, neural, and ocular physiologynervous system
free text keywords: RC0321
Related Organizations
36 references, page 1 of 3

Andrisfalvy BK, Smith MA, Borchardt T, Sprengel R, Magee JC (2003) Im ­ paired regulation o f synaptic strength in hippocampal neurons from G luRl-deficient mice. J Physiol 552:35-45.

Bayazitov IT, Richardson RJ, Fricke RG, Zakharenko SS (2007) Slow presynaptic and fast postsynaptic com ponents o f com pound long-term potentiation. J Neurosci 27:11510-11521. [OpenAIRE]

Blackshaw S, Eliasson MJ, Sawa A, Watkins CC, Krug D, Gupta A, Arai T, Ferrante RJ, Snyder SH (2003) Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity. Neuroscience 119:979-990. [OpenAIRE]

Bliss TV, Lomo T (1973) Long-lasting potentiation o f synaptic transmission in the dentate area o f the anaesthetized rabbit following stimulation o f the perforant path. J Physiol 232:331-356. [OpenAIRE]

Chetkovich DM, Klann E, Sweatt JD (1993) Nitric oxide synthaseindependent long-term potentiation in area CA1 o f hippocampus. N euroreport 4:919-922. [OpenAIRE]

Eliasson MJ, Blackshaw S, Schell MJ, Snyder SH (1997) Neuronal nitric o x ­ ide synthase alternatively spliced forms: prominent functional localizations in the brain. Proc Natl Acad Sci U S A 94:3396-3401. [OpenAIRE]

Golding NL, Staff NP, Spruston N (2002) Dendritic spikes as a mechanism for cooperative long-term potentiation. Nature 418:326-331.

Gribkoff VK, Lum-Ragan JT (1992) Evidence for nitric oxide synthase inhibitor-sensitive and insensitive hippocampal synaptic potentiation. J Neurophysiol 68:639-642. [OpenAIRE]

Haley JE, Wilcox GL, Chapman PF (1992) The role o f nitric oxide in hippocampal long-term potentiation. Neuron 8:211-216.

Haley JE, Malen PL, Chapman PF (1993) Nitric oxide synthase inhibitors block long-term potentiation induced by weak but not strong tetanic stimulation at physiological brain temperatures in rat hippocampal slices. Neurosci Lett 160:85-88.

Hardingham N, Fox K (2006) The role o f nitric oxide and GluRl in presynaptic and postsynaptic com ponents o f neocortical potentiation. JN eurosci 26:7395-7404. [OpenAIRE]

Hawkins RD, Son H, Arancio O (1998) Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus. Prog Brain Res 118:155-172. [OpenAIRE]

Hoffman DA, Sprengel R, Sakmann B (2002) Molecular dissection o f hippocampal theta-burst pairing potentiation. Proc Natl Acad Sci U S A 99:7740-7745. [OpenAIRE]

Hblscher C (1997) Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity. Trends Neurosci 20:298-303.

Holscher C (2002) Different strains o f rats show different sensitivity to block o f long-term potentiation by nitric oxide synthase inhibitors. Eur J Pharmacol 457:99-106. [OpenAIRE]

36 references, page 1 of 3
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