publication . Thesis

The role of nitric oxide and somatic action potentials in a GluR1 independent LTP

Phillips, Keith Geoffrey;
Open Access English
  • Country: United Kingdom
Studies in GluRl knockout mice have shown that neocortical LTP consist of both pre- and post-synaptic components that rely on nitric oxide and GluRl respectively (Hardingham and Fox, 2006). Given that GluRl knockout also show hippocampal LTP (Hoffmann et al., 2002) I hypothesised that the residual LTP might depend on nitric oxide. I have found that hippocampal LTP can be induced in GluRl knockout with purely orthodromic stimuli in mature mice (>8weeks) and that a theta-burst protocol was effective at inducing LTP while 100Hz stimulation was not. I found that only theta-burst stimulation produced reliable post-synaptic spikes, while 100Hz stimulation produced rel...
Medical Subject Headings: musculoskeletal, neural, and ocular physiologynervous system
free text keywords: RC0321
Related Organizations
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