Some model studies for vitamin B12 dependent enzymic reactions
Atkins, Martin Philip;
Vitamin B12 catalyses a variety of important reactions in metabolic pathways. Impairment of vitamin B12 by man leads to deficiency diseases e.g. pernicious anaemia. Many mechanistic possibilities have been suggested to account for the transformation of organic substrate... View more
3:3(«) Experimental 49. Results and Discussion 58.
3:*t(a) « C labelling Study of the Rearrangement of Cyclopropylmethyl- to But-3-enyl(pyridine)cobaloxime 3:^(b) Kinetics and Activation Parameters for the Rearrangement of Cyclopropylmethyl(pyridine)cobaloxime 73.
3:<t(c) Solvent and Axial Base Dependence of the Rearrangement of Cyclopropylmethyl- to But-3-enyl(pyridine)cobaloxime 7.
3:3 Stabilities of Cyclopropylmethyl Cations and Radicals 80• 3:5^a) Cyclopropylmethyl carbonium ions 3*5(B) Cyclopropylmethyl Radicals 89.
1. "Rearrangements of Cyclopropylmethyl- and Sut-3-enylcobaloximes". M.P.Atkins, B.T.Golding and P.J.Sellars, J.C.S. Chem. Comm., 1979, 954.
?. "Models for Cobalamin-dependent Snzymatic Heactions", M.P.Atkins, 9. f. Golding, C.S.Sell and P.J.Sellars; Lecture presented at Autumn Meeting of the Chemical Society held at University of Warwick, Sept. 1978.
3. "Model Systems for Adenosylcobalanin Dependent Snzymatic Keactions“, K.P.Atkins, B.T.Golding and P.J.Sellars, Third European Symposium on Vitamin 3 ^ , Zurich, .'.'Arch 1979«
4. "Mechanistic Studies using 1 '*C-Label3", M.F.Atkins, D.C.flillington, 3.T.Golding, M.D.Johnson, I.K.Nassereddin and P.J.Sellars; Paper presented at "Symposium on Stable Isotopes”, University of Warwick, Sept. 1979.
5. V -Homoallylcobalt Complexes in the Intramolecular Rearrangements of 3ut-3-enylcobaloximes", M.P.Atkins, 3.T.Golding, M.D.Johnson and P.J.