Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.

Article English OPEN
van Schalkwyk, DA; Nash, MN; Shafik, SH; Summers, RL; Lehane, AM; Smith, PJ; Martin, RE;
  • Publisher: Oxford University Press (OUP)
  • Subject:
    mesheuropmc: parasitic diseases

It is becoming increasingly apparent that certain mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) alter the parasite's susceptibility to diverse compounds. Here we investigated the interaction of PfCRT with 3 tricyclic compounds that ha... View more