Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake

Article English OPEN
Adams, J P; Holder, A L; Catchpole, B;
(2014)

Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in terms of its manufac... View more
  • References (5)

    Peavy, D.E., Brunner, M.R., Duckworth, W.C., Hooker, C.S., Frank, B.H., 1985. Receptor binding and biological potency of several split forms (conversion intermediates) of human proinsulin. Studies in cultured IM-9 lymphocytes and in vivo and in vitro in rats. Journal of Biological Chemistry 260, 13989-13994.

    Pullen, R.A., Lindsay, D.G., Wood, S.P., Tickle, I.J., Blundell, T.L., Wollmer, A., Krail, G., Brandenburg, D., Zahn, H., Gliemann, J., Gammeltoft, S., 1976. Receptor-binding region of insulin. Nature 259, 369-373.

    Rajpal, G., Liu, M., Zhang, Y., Arvan, P., 2009. Single-chain insulins as receptor agonists. Molecular Endocrinology 23, 679-688.

    Riggs, A.D., Itakura, K., 1979. Synthetic DNA and medicine. American Journal of Human Genetics 31, 531-538.

    Rucinsky, R., Cook, A., Haley, S., Nelson, R., Zoran, D.L., Poundstone, M., 2010. AAHA diabetes management guidelines for dogs and cats. Journal of the American Animal Hospital Association 46, 215-224.

  • Metrics
Share - Bookmark