What is the evidence that the putative Mycobacterium lepromatosis species causes diffuse lepromatous leprosy?

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Gillis, TP ; Scollard, DM ; Lockwood, DN (2011)
  • Publisher: British Leprosy Relief Assoc

: Han et al. have made a retrospective isolation of DNA from two patients with fatal Lucio's phenomenon. This DNA does have some molecular differences to M. leprae and may constitute a variant of M. leprae. However the experiments and data needed to confirm that this is a new leprosy-causing species have not yet been done. We have outlined the work that does need to be done. For the moment the assertion that 'M. lepromatosis' is a new leprosy-causing species is not proven.<br/>
  • References (12)
    12 references, page 1 of 2

    1 Han XY, Seo Y-H, Sizer KC et al. A new Mycobacterium species causing diffuse lepromatous leprosy. Am J Clin Path, 2008; 130: 856- 864.

    2 Han XY, Sizer KC, Thompson EJ et al. Comparative sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium lepromatosis. J Bacteriol, 2009; 191: 6067 - 6074.

    3 Rea TH. Lucio's phenomenon: an overview. Lepr Rev, 1979; 50: 107- 112.

    4 Rea TH, Jerskey RS. Clinical and histologic variations among thirty patients with Lucio's phenomenon and pure and primitive diffuse lepromatosis (Latapi's lepromatosis). Int J Lepr Other Mycobact Dis, 2005; 73: 169 - 188.

    5 Tindall BJ, Rossello-Mora R, Busse H-J et al. Notes on the characterization of prokaryote strains for taxonomic purposes. Int J Systematic and Evolutionary Microbiol, 2010; 60: 249 - 266.

    6 Scollard DM, Stryjewska BM, Prestigacomo JF et al. Hansen's disease (leprosy) complicated by secondary mycobacterial infection. J Am Acad Dermatol, 2011; 64: 593 - 596.

    7 Monot M, Honore N, Garnier T et al. Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet, 2009; 41: 1282 - 1289.

    8 Cole ST, Eiglmeier K, Parkhill J et al. Massive gene decay in the leprosy bacillus. Nature, 2001; 409: 1007 - 1011.

    9 Fredricks DN, Relman DA. Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin Microbiol Rev, 1996; 9: 18 - 33.

    10 Latapi F, Zamora AC. The 'spotted' leprosy of Lucio (la lepra 'manchada' de Lucio). Int J Lepr Other Mycobact Dis, 1948; 16: 421- 437.

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