publication . Article . 2018

A theoretical model of inflammation- and mechanotransduction- driven asthmatic airway remodelling

Michael R. Hill; Christopher J. Philp; Charlotte K. Billington; Amanda L. Tatler; Simon R. Johnson; Reuben D. O’Dea; Bindi S. Brook;
Open Access English
  • Published: 01 Jul 2018
  • Publisher: Springer Verlag
  • Country: Italy
Abstract
Inflammation, airway hyper-responsiveness and airway remodelling are well-established hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better understanding of their inter-dependence, we develop a mechanochemical morphoelastic model of the airway wall accounting for local volume changes in airway smooth muscle (ASM) and extracellular matrix in response to transient inflammatory or contractile agonist challenges. We use constrained mixture theory, together with a multiplicative decomposition of growth from the elastic deformation, to model the airway wall as a nonlinear fibre-reinforced elastic cylinder. Local contractile ago...
Subjects
Medical Subject Headings: respiratory tract diseasesrespiratory system
free text keywords: Original Paper, Morphoelastic, Bronchoconstriction, Hyper-responsiveness, Mechanochemical, Airway smooth muscle, Multiphase, Biotechnology, Mechanical Engineering, Modelling and Simulation, Cell contraction, Neuroscience, Agonist, medicine.drug_class, medicine, Materials science, Decomposition analysis, Mechanotransduction, Inflammation, medicine.symptom, Anatomy, Airway Remodelling, Extracellular matrix, Airway
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