publication . Article . 2011

Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI

Cole, Laura; Djidja, M-C; Bluff, J.; Claude, E; Carolan, Vikki; Paley, M; Tozer, G M; Clench, Malcolm;
Open Access English
  • Published: 01 Jan 2011
  • Publisher: Academic Press
Abstract
Characterising the protein signatures in tumours following vascular-targeted therapy will help determine both treatment response and resistance mechanisms. Here, mass spectrometry imaging and MS/MS with and without ion mobility separation have been used for this purpose in a mouse fibrosarcoma model following treatment with the tubulin-binding tumour vascular disrupting agent, combretastatin A-4-phosphate (CA-4-P). Characterisation of peptides after in-situ tissue tryptic digestion was carried out using Matrix Assisted Laser Desorption Ionisation- Mass Spectrometry (MALDI-MS) and Matrix Assisted Laser Desorption Ionisation- Ion Mobility Separation- Mass Spectrom...
27 references, page 1 of 2

1) Hanahan D and Weinberg RA (2000) The hallmarks of cancer. Cell. 100. 57- 70 [OpenAIRE]

2) Lord CJ and Ashworth A (2010) Biology-driven cancer drug development: back to the future. BMC Biology. 8. (38) 1-12

3) Kanthou and Tozer (2007) Selective destruction of the tumour vasculature by targeting the endothelial cytoskeleton. Drug discovery today: Therapeutic strategies. 4. (4) 237-243

4) Thorpe PE, Chaplin DJ, Blakey DC (2003) The first international conference on vascular targeting: Meeting overview. Cancer Research. 63. 1144-1147

5) Zhi-chao SI, Jie L (2008) What 'helps' tumours evade vascular targeting treatment? Chinese Medical Journal. 121. (9) 844-849

6) Tozer GM, Kanthou C, Lewis G, Prise VE, Vojnovic B, Hill A (2008) Tumour vascular disrupting agents: combating treatment resistance. The British Journal of Radiology. 81. S12-S20

7) Abdollahi A, Folkman J (2010) Evading tumour evasion: Current concepts and perspectives of anti-angiogenic cancer therapy. Drug Resistance Updates. 13. 16-28

8) Kanthou C and Tozer GM (2009) Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies International Journal of Experimental Pathology 80. 284-294. [OpenAIRE]

9) Siemann W. (2009) "Vascular targeted therapies in oncology" Cell and Tissue Research 335. 241-248.

10) Caprioli, R. M., Farmer T.B. and Gile J. (1997) Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS Anal. Chem. 69, 4751-4760.

11) Chaurand, P.; Cornett, D. S.; Caprioli, R. M. (2006) Molecular imaging of thin mammalian tissue sections by mass spectrometry Curr. Opin. Biotechnol. 17, 431- 436.

12) Chaurand, P.; Fouchécourt, S.; DaGue, B. B.; Xu, B. J.; Reyzer, M. L.; Orgebin-Crist, M.; Caprioli, R. M. (2003) Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry Proteomics, 3, 2221-2239.

13) Stoeckli, M.; Staab, D.; Schweitzer, A.; Gardiner, J.; Seebach, D. (2007) Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry J. Am. Soc. Mass Spectrom. 18, 1921-1924.

14) Burrell, M.; Earnshaw, C.; Clench, M. (2007) Imaging Matrix Assisted Laser Desorption Ionization Mass Spectrometry: a technique to map plant metabolites within tissues at high spatial resolution J. Exp. Bot. 58, 757-763.

15) Djidja, M.; Carolan, V.; Loadman, P. M.; Clench, M. R. (2008) Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging Rapid Commun. Mass Spectrom. 22, 1615-1618.

27 references, page 1 of 2
Abstract
Characterising the protein signatures in tumours following vascular-targeted therapy will help determine both treatment response and resistance mechanisms. Here, mass spectrometry imaging and MS/MS with and without ion mobility separation have been used for this purpose in a mouse fibrosarcoma model following treatment with the tubulin-binding tumour vascular disrupting agent, combretastatin A-4-phosphate (CA-4-P). Characterisation of peptides after in-situ tissue tryptic digestion was carried out using Matrix Assisted Laser Desorption Ionisation- Mass Spectrometry (MALDI-MS) and Matrix Assisted Laser Desorption Ionisation- Ion Mobility Separation- Mass Spectrom...
27 references, page 1 of 2

1) Hanahan D and Weinberg RA (2000) The hallmarks of cancer. Cell. 100. 57- 70 [OpenAIRE]

2) Lord CJ and Ashworth A (2010) Biology-driven cancer drug development: back to the future. BMC Biology. 8. (38) 1-12

3) Kanthou and Tozer (2007) Selective destruction of the tumour vasculature by targeting the endothelial cytoskeleton. Drug discovery today: Therapeutic strategies. 4. (4) 237-243

4) Thorpe PE, Chaplin DJ, Blakey DC (2003) The first international conference on vascular targeting: Meeting overview. Cancer Research. 63. 1144-1147

5) Zhi-chao SI, Jie L (2008) What 'helps' tumours evade vascular targeting treatment? Chinese Medical Journal. 121. (9) 844-849

6) Tozer GM, Kanthou C, Lewis G, Prise VE, Vojnovic B, Hill A (2008) Tumour vascular disrupting agents: combating treatment resistance. The British Journal of Radiology. 81. S12-S20

7) Abdollahi A, Folkman J (2010) Evading tumour evasion: Current concepts and perspectives of anti-angiogenic cancer therapy. Drug Resistance Updates. 13. 16-28

8) Kanthou C and Tozer GM (2009) Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies International Journal of Experimental Pathology 80. 284-294. [OpenAIRE]

9) Siemann W. (2009) "Vascular targeted therapies in oncology" Cell and Tissue Research 335. 241-248.

10) Caprioli, R. M., Farmer T.B. and Gile J. (1997) Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS Anal. Chem. 69, 4751-4760.

11) Chaurand, P.; Cornett, D. S.; Caprioli, R. M. (2006) Molecular imaging of thin mammalian tissue sections by mass spectrometry Curr. Opin. Biotechnol. 17, 431- 436.

12) Chaurand, P.; Fouchécourt, S.; DaGue, B. B.; Xu, B. J.; Reyzer, M. L.; Orgebin-Crist, M.; Caprioli, R. M. (2003) Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry Proteomics, 3, 2221-2239.

13) Stoeckli, M.; Staab, D.; Schweitzer, A.; Gardiner, J.; Seebach, D. (2007) Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry J. Am. Soc. Mass Spectrom. 18, 1921-1924.

14) Burrell, M.; Earnshaw, C.; Clench, M. (2007) Imaging Matrix Assisted Laser Desorption Ionization Mass Spectrometry: a technique to map plant metabolites within tissues at high spatial resolution J. Exp. Bot. 58, 757-763.

15) Djidja, M.; Carolan, V.; Loadman, P. M.; Clench, M. R. (2008) Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging Rapid Commun. Mass Spectrom. 22, 1615-1618.

27 references, page 1 of 2
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