publication . Article . 2018

Survival analysis with delayed entry in selected families with application to human longevity.

Mar Rodríguez-Girondo; Deelen J; Ep, Slagboom; Jj, Houwing-Duistermaat;
  • Published: 01 Jan 2018
Abstract
In the field of aging research, family-based sampling study designs are commonly used to study the lifespans of long-lived family members. However, the specific sampling procedure should be carefully taken into account in order to avoid biases. This work is motivated by the Leiden Longevity Study, a family-based cohort of long-lived siblings. Families were invited to participate in the study if at least two siblings were ‘long-lived’, where ‘long-lived’ meant being older than 89 years for men or older than 91 years for women. As a result, more than 400 families were included in the study and followed for around 10 years. For estimation of marker-specific surviva...
Subjects
free text keywords: Cohort, Survival analysis, Clinical study design, Gerontology, Human longevity, Survival data, Sampling (statistics), Longevity, media_common.quotation_subject, media_common, Mathematics, Statistics, Inverse probability weighting
Related Organizations
Funded by
EC| MIMOMICS
Project
MIMOMICS
Methods for Integrated analysis of Multiple Omics datasets
  • Funder: European Commission (EC)
  • Project Code: 305280
  • Funding stream: FP7 | SP1 | HEALTH

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