publication . Other literature type . Article . 2004

Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

Amadesi, Silvia; Nie, J.; Vergnolle, N.; Cottrell, Graeme S.; Grady, E. F.; Trevisani, M.; Manni, C.; Geppetti, P.; McRoberts, J. A.; Ennes, H.; ...
Open Access English
  • Published: 05 May 2004
  • Publisher: Society for Neuroscience
  • Country: United Kingdom
Abstract
Inflammatory proteases (mast cell tryptase and trypsins) cleave protease-activated receptor 2 (PAR(2)) on spinal afferent neurons and cause persistent inflammation and hyperalgesia by unknown mechanisms. We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated by capsaicin, protons, and noxious heat, mediates PAR(2)-induced hyperalgesia. PAR(2) was coexpressed with TRPV1 in small- to medium-diameter neurons of the dorsal root ganglia (DRG), as determined by immunofluorescence. PAR(2) agonists increased intracellular [Ca(2+)] ([Ca(2+)](i)) in these neurons in culture, and PAR(2)-responsive neurons also responded ...
Subjects
Medical Subject Headings: nervous systemlipids (amino acids, peptides, and proteins)musculoskeletal, neural, and ocular physiology
free text keywords: Cellular/Molecular, Biology, Receptor, Pharmacology, Agonist, medicine.drug_class, medicine, Capsaicin, chemistry.chemical_compound, chemistry, TRPV1, Transient receptor potential channel, Endocrinology, medicine.medical_specialty, Protease-activated receptor 2, Hyperalgesia, medicine.symptom, Protein kinase C, Biochemistry, Internal medicine
Funded by
NIH| REGULATION OF SIGNALING BY CELL SURFACE PROTEOLYSIS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK043207-05
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK052388-08
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
64 references, page 1 of 5

Abdulla FA, Smith PA (1997) Nociceptin inhibits T-type Ca 2 channel current in rat sensory neurons by a G-protein-independent mechanism. J Neurosci 17:8721- 8728.

Ahern GP, Premkumar LS (2002) Voltage-dependent priming of rat vanilloid receptor: effects of agonist and protein kinase C activation. J Physiol (Lond) 545:441- 451. [OpenAIRE]

Aley KO, Messing RO, Mochly-Rosen D, Levine JD (2000) Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci 20:4680 - 4685. [OpenAIRE]

Alm AK, Gagnemo-Persson R, Sorsa T, Sundelin J (2000) Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2. Biochem Biophys Res Commun 275:77- 83.

Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N (2002) Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br J Pharmacol 135:1101-1106. [OpenAIRE]

Belanger S, Ma W, Chabot JG, Quirion R (2002) Expression of calcitonin gene-related peptide, substance P and protein kinase C in cultured dorsal root ganglion neurons following chronic exposure to mu, delta and kappa opiates. Neuroscience 115:441- 453. [OpenAIRE]

Bohm SK, Khitin LM, Grady EF, Aponte G, Payan DG, Bunnett NW (1996) Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J Biol Chem 271:22003-22016.

Camerer E, Huang W, Coughlin SR (2000) Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 97:5255-5260. [OpenAIRE]

Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816 - 824.

Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306 -313. [OpenAIRE]

Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N (2002) Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol 161:1903-1915. [OpenAIRE]

Cenac N, Garcia-Villar R, Ferrier L, Larauche M, Vergnolle N, Bunnett NW, Coelho AM, Fioramonti J, Bueno L (2003) Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. J Immunol 170:4296 - 4300. [OpenAIRE]

Cesare P, Moriondo A, Vellani V, McNaughton PA (1999) Ion channels gated by heat. Proc Natl Acad Sci USA 96:7658 -7663. [OpenAIRE]

Chan CL, Facer P, Davis JB, Smith GD, Egerton J, Bountra C, Williams NS, Anand P (2003) Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet 361:385-391.

Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411:957-962.

64 references, page 1 of 5
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2004

Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

Amadesi, Silvia; Nie, J.; Vergnolle, N.; Cottrell, Graeme S.; Grady, E. F.; Trevisani, M.; Manni, C.; Geppetti, P.; McRoberts, J. A.; Ennes, H.; ...