BclA and toxin antigens augment each other to protect NMRI mice from lethal Bacillus anthracis challenge

Article English OPEN
Köhler, Susanne M.; Baillie, Les; Beyer, Wolfgang;

While proving highly effective in controlling Anthrax in farm animals all over the world currently attenuated live anthrax vaccines employed in a veterinary context suffer from drawbacks such as residual virulence, short term protection, variation in quality and, most i... View more
  • References (20)
    20 references, page 1 of 2

    [1] Turnbull PCB. Introduction: Anthrax History, Disease and Ecology. In: Koehler TM, editors. Anthrax. Current topics in microbiology and immunology, Berlin Heidelberg: Springer-Verlag; 2002, p. 1-19.

    [2] Dixon TC, Meselson M, Guillemin J, Hanna PC. Anthrax. N Engl J Med 1999; 341:815-26.

    [3] Uchida I, Sekizaki T, Hashimoto K, Terakado N. Association of the Encapsulation of Bacillus anthracis with a 60 Megadalton Plasmid. J Gen Microbiol 1985; 131:363-7.

    [4] Mikesell P, Ivins BE, Ristroph JD, Dreier TM. Evidence for Plasmid-Mediated Toxin Production in Bacillus anthracis. Infect Immun 1983; 39:371-6.

    [5] Smith H, Keppie J, Stanley JL. The chemical basis of the virulence of Bacillus anthracis. V: The specific toxin produced by B. anthracis in vivo. Br J Exp Pathol 1955; 36:460-72.

    [6] Leppla SH. Anthrax Toxin. In: Aktories K, Just I, editors. Bacterial protein toxins, Berlin Heidelberg: Springer-Verlag; 2000, p. 445-72.

    [7] Turnbull PCB. Anthrax vaccines: past, present and future. Vaccine 1991; 9:533-9.

    [8] Stepanov AV, Marinin LI, Pomerantsev AP, Staritsin NA. Development of novel vaccines against anthrax in man. J Bacteriol 2006; 44:155-160.

    [9] Little S, Ivins B, Fellows P, Pitt M, Norris S, Andrews G. Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine. Vaccine 2004; 22:422-30.

    [10] Price BM, Liner AL, Park S, Leppla SH, Mateczun A, Galloway DR. Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor Protein. Infect Immun 2001; 69:4509-15.

  • Metrics
Share - Bookmark