publication . Other literature type . Article . 2006

Down-regulation of MHC class I is a property common to papillomavirus E5 proteins

Ashrafi, G.H.; Brown, D.R.; Fife, K.H.; Campo, M.S.;
  • Published: 01 Sep 2006
  • Publisher: Elsevier BV
  • Country: India
Abstract
The E5 protein family of papillomaviruses comprises small hydrophobic proteins which are associated with the cell endomembrane compartments. The functions of the E5 proteins, particularly those of HPV, are still far from clear. We have reported that the E5 proteins of BPV-1, BPV-4, HPV-16 and HPV-6 down-regulate MHC class I, potentially helping the virus evade the host immune response. Others have described MHC class I down-regulation by HPV-2 E5. We report here that another E5 protein, HPV-83 E5, likewise down-regulates MHC class I and propose that interference with expression, assembly and/or transport of MHC class I is a common property of all E5 proteins evo...
Subjects
Medical Subject Headings: viruses
free text keywords: Cancer Research, Virology, Infectious Diseases, Antigen processing, Biology, MHC class I, biology.protein, Endomembrane system, CD74, Immunosurveillance, Genetics, MHC restriction, Protein family, Viral Interference, QR180, SF600
Related Organizations
20 references, page 1 of 2

Araibi, E.H., Marchetti, B., Ashrafi, G.H., Campo, M.S., 2004. Down-regulation of MHC class I in bovine papillomas. J. Gen. Virol. 85, 2809-2814. [OpenAIRE]

Ashrafi, G.H., Haghshenas, M.R., Marchetti, B., O'Brien, P.M., Campo, M.S., 2005. The E5 protein of human papillomavirus type 16 selectively down-regulates surface HLA class. Int. J. Cancer 113, 276-283. [OpenAIRE]

Ashrafi, G.H., Tsirimonaki, E., Marchetti, B., O'Brien, P.M., Sibbet, G.J., Andrew, L., Campo, M.S., 2002. Downregulation of MHC class I by bovine papillomavirus E5 oncoproteins. Oncogene 21, 248-259. [OpenAIRE]

Ashrafi, G.H., Haghshenas, M., Marchetti, B., Campo, M.S., 2006. E5 protein of Human Papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain. International Journal of Cancer, 119, 2105-2112. [OpenAIRE]

Bernard, H.U., 2005. The clinical importance of the nomenclature, evolution and taxonomy of human papillomaviruses. J. Clin. Virol. 32 (Suppl. 1), S1-S6. [OpenAIRE]

Bravo, I.G., Alonso, A., 2004. Mucosal human papillomaviruses encode four different E5 proteins whose chemistry and phylogeny correlate with malignant or benign growth. J. Virol. 78, 13613-13626.

Broker, T.R., Jin, G., Croom-Rivers, A., Bragg, S.M., Richardson, M., Chow, L.T., Vermund, S.H., Alvarez, R.D., Pappas, P.G., Squires, K.E., Hoesley, C.J., 2001. Viral latency-the papillomavirus model. Dev. Biol. (Basel) 106, 443-451. [OpenAIRE]

Brown, D., Legge, D., Qadadri, B., 2002. Distribution of human papillomavirus types in cervicovaginal washings from women evaluated in a sexually transmitted diseases clinic. Sex. Transm. Dis. 29, 763-768.

Brown, D.R., McClowry, T.L., Bryan, J.T., Stoler, M., Schroeder-Diedrich, J.M., Fife, K.H., 1998. A human papillomavirus related to human papillomavirus MM7/LVX82 produces distinct histological abnormalities in human foreskin implants grown as athymic mouse xenografts. Virology 249, 150-159. [OpenAIRE]

Brown, D.R., McClowry, T.L., Woods, K., Fife, K.H., 1999. Nucleotide sequence and characterization of human papillomavirus type 83, a novel genital papillomavirus. Virology 260, 165-172. [OpenAIRE]

Cartin, W., Alonso, A., 2003. The human papillomavirus HPV2a E5 protein localizes to the Golgi apparatus and modulates signal transduction. Virology 314, 572-579.

Chaturvedi, A.K., Dumestre, J., Gaffga, A.M., Mire, K.M., Clark, R.A., Braly, P.S., Dunlap, K., Beckel, T.E., Hammons, A.F., Kissinger, P.J., Hagensee, M.E., 2005. Prevalence of human papillomavirus genotypes in women from three clinical settings. J. Med. Virol. 75, 105-113.

Cresswell, P., Bangia, N., Dick, T., Dietrich, G., 1999. The nature of the MHC class I peptide loading complex. Immunol. Rev. 172, 21-28.

de Villiers, E.M., Fauquet, C., Broker, T.R., Bernard, H.U., zur Hausen, H., 2004. Classification of papillomaviruses. Virology 324, 17-27. [OpenAIRE]

Giuliano, A.R., Harris, R., Sedjo, R.L., Baldwin, S., Roe, D., Papenfuss, M.R., Abrahamsen, M., Inserra, P., Olvera, S., Hatch, K., 2002. Incidence, prevalence, and clearance of type-specific human papillomavirus infections: the young women's health study. J. Infect. Dis. 186, 462-469.

20 references, page 1 of 2
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