publication . Other literature type . Article . 2006

Down-regulation of MHC class I is a property common to papillomavirus E5 proteins

Ashrafi, G.H.; Brown, D.R.; Fife, K.H.; Campo, M.S.;
  • Published: 01 Sep 2006
  • Publisher: Elsevier BV
  • Country: India
The E5 protein family of papillomaviruses comprises small hydrophobic proteins which are associated with the cell endomembrane compartments. The functions of the E5 proteins, particularly those of HPV, are still far from clear. We have reported that the E5 proteins of BPV-1, BPV-4, HPV-16 and HPV-6 down-regulate MHC class I, potentially helping the virus evade the host immune response. Others have described MHC class I down-regulation by HPV-2 E5. We report here that another E5 protein, HPV-83 E5, likewise down-regulates MHC class I and propose that interference with expression, assembly and/or transport of MHC class I is a common property of all E5 proteins evo...
Medical Subject Headings: viruses
free text keywords: Cancer Research, Virology, Infectious Diseases, Antigen processing, Biology, MHC class I, biology.protein, Endomembrane system, CD74, Immunosurveillance, Genetics, MHC restriction, Protein family, Viral Interference, QR180, SF600
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