publication . Article . 2016

A novel regulatory role for tissue transglutaminase in epithelial-mesenchymal transition in cystic fibrosis

Nyabam, Samuel; Wang, Zhuo; Thibault, Thomas; Ayinde, Oluseyi; Basar, Rameeza; Marshall, Lindsay; Griffin, Martin;
Open Access English
  • Published: 01 Sep 2016
  • Country: United Kingdom
Cystic fibrosis (CF) is a genetic disorder caused by mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) for which there is no overall effective treatment. Recent work indicates tissue transglutaminase (TG2) plays a pivotal intracellular role in proteostasis in CF epithelia and that the pan TG inhibitor cysteamine improves CFTR stability. Here we show TG2 has another role in CF pathology linked with TGFβ1 activation and signalling, induction of epithelial-mesenchymal transition (EMT), CFTR stability and induction of matrix deposition. We show that increased TG2 expression in normal and CF bronchial epithelial cells increases TGFβ1 levels, ...
Related Organizations
Funded by
The Commercialisation of Transglutaminase.
  • Funder: European Commission (EC)
  • Project Code: 251506
  • Funding stream: FP7 | SP3 | PEOPLE
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