Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053)

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Appleton, Jason P..; Scutt, Polly.; Dixon, Mark.; Howard, Harriet.; Haywood, Lee.; Havard, Diane.; Hepburn, Trish.; England, Timothy J..; Sprigg, Nikola.; Woodhouse, Lisa J..; Wardlaw, Joanna M..; Montgomery, Alan A..; Pocock, Stuart J..; Bath, Philip M.W..;
  • Publisher: SAGE Publications (UK and US)
  • Subject: Acute stroke, ambulance, antihypertensive therapy, cerebrovascular disorders, glyceryl trinitrate, nitroglycerin, paramedic, randomized controlled trial

Rationale: Vascular nitric oxide levels are low in acute stroke and donors such as glyceryl trinitrate have shown promise when administered very early after stroke. Potential mechanisms of action include augmentation of cerebral reperfusion, thrombolysis and thrombectom... View more
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