Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

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Day, FR; Ruth, KS; Thompson, DJ; Lunetta, KL; Pervjakova, N; Chasman, DI; Stolk, L; Finucane, HK; Sulem, P; Bulik-Sullivan, B; Esko, T; Johnson, AD; Elks, CE; Franceschini, N; He, C; Altmaier, E; Brody, JA; Franke, LL; Huffman, JE; Keller, MF; McArdle, PF; Nutile, T; Porcu, E; Robino, A; Rose, LM; Schick, UM; Smith, JA; Teumer, A; Traglia, M; Vuckovic, D; ... view all 243 authors
  • Publisher: Nature Publishing Group

Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~70,000 women to identify common and low-frequency protein-coding variation associate... View more
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