Tripodal molecules for the promotion of phosphoester hydrolysis

Article English OPEN
Hiscock, Jennifer R. ; Sambrook, Mark R. ; Cranwell, Philippa B, ; Watts, Pat ; Vincent, Jack C. ; Xuereb, David J. ; Wells, Neil J. ; Raja, Robert ; Gale, Philip A. (2014)

A series of low molecular weight tripodal amide/histidine-containing compounds (1–2) have been synthesised and shown to increase the rate of bis-(p-nitrophenyl) phosphate (BNPP) and soman (GD) breakdown in buffered aqueous solution.
  • References (15)
    15 references, page 1 of 2

    1 K. Kim, O. G. Tsay, D. A. Atwood and D. G. Churchill, Chem. Rev., 2011, 111, 5345-5403.

    2 M. R. Sambrook, J. R. Hiscock, A. Cook, A. C. Green, I. Holden, J. C. Vincent and P. A. Gale, Chem. Commun., 2012, 48, 5605-5607.

    3 J. R. Hiscock, F. Piana, M. R. Sambrook, N. J. Wells, A. J. Clark, J. C. Vincent, N. Busschaert, R. C. D. Brown and P. A. Gale, Chem. Commun., 2013, 49, 9119-9121.

    4 A. Blasko and T. C. Bruice, Acc. Chem. Res., 1999, 32, 475-484.

    5 P. Dydio, W. I. Dzik, M. Lutz, B. de Bruin and J. N. H. Reek, Angew. Chem., Int. Ed., 2011, 50, 396-400.

    6 F. Giacalone, M. Gruttadauria, P. Agrigento and R. Noto, Chem. Soc. 16 Y. Ma, X. Chen, M. Sun, R. Wan, C. Zhu, Y. Li and Y. Zhao, Rev., 2012, 41, 2406-2447. Amino Acids, 2008, 35, 251-256.

    7 R. Salvio, R. Cacciapaglia and L. Mandolini, J. Org. Chem., 2011, 76, 17 C. Schmuck, U. Michels and J. Dudaczek, Org. Biomol. Chem., 2009, 5438-5443. 7, 4362-4368.

    8 B. M. Smith, Chem. Soc. Rev., 2008, 37, 470-478. 18 R. Breslow, P. Bovy and C. L. Hersh, J. Am. Chem. Soc., 1980, 102,

    9 A. Sreedhara and J. A. Cowan, J. Biol. Inorg. Chem., 2001, 6, 337-347. 2115-2117.

    10 J. E. Taylor, S. D. Bull and J. M. J. Williams, Chem. Soc. Rev., 2012, 41, 19 R. Breslow, J. B. Doherty, G. Guillot and C. Lipsey, J. Am. Chem. Soc., 2109-2121; N. H. Williams, B. Takasaki, M. Wall and J. Chin, Acc. 1978, 100, 3227-3229. Chem. Res., 1999, 32, 485-493. 20 M. Merschky and C. Schmuck, Org. Biomol. Chem., 2009, 7,

  • Metrics
    No metrics available
Share - Bookmark