publication . Article . Other literature type . 2017

Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model

Alam Zeb; Omer Salman Qureshi; Chan-Hee Yu; Muhammad Akram; Hyung-Seo Kim; Myung-Sic Kim; Jong-Ho Kang; Arshad Majid; Sun-Young Chang; Ok-Nam Bae; ...
Closed Access English
  • Published: 15 Jun 2017
  • Publisher: Elsevier
  • Country: United Kingdom
Abstract
Abstract The aim of this study is to investigate in vivo anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel (MTX-UDLs-gel) in adjuvant-induced arthritis rat model. Methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) with the optimal phosphatidylcholine to Tween 80 ratio (7:3, w/w) were incorporated into 1% Carbopol gel. MTX-UDLs-gel was characterized in terms of appearance, clarity, homogeneity, pH and drug content. The permeation of MTX-UDLs-gel across rat skin was investigated using Franz diffusion cell. In vivo anti-rheumatic activity of MTX-UDLs-gel was assessed in terms of edema volume, paw edema and leukocyte infiltrati...
Subjects
Medical Subject Headings: musculoskeletal diseasesskin and connective tissue diseasesheterocyclic compounds
free text keywords: In vivo, Inflammation, medicine.symptom, medicine, Liposome, Chemistry, Proinflammatory cytokine, Pharmacology, Pathology, medicine.medical_specialty, Chromatography, Edema, Arthritis, medicine.disease, Rheumatoid arthritis, Methotrexate, medicine.drug
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