publication . Article . Other literature type . 2018

Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells

Houghton, MJ; Kerimi, A; Tumova, S; Boyle, JP; Williamson, G;
Open Access
  • Published: 01 Dec 2018 Journal: Free Radical Biology and Medicine, volume 129, pages 296-309 (issn: 0891-5849, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Abstract Hyperglycemia augments formation of intracellular reactive oxygen species (ROS) with associated mitochondrial damage and increased risk of insulin resistance in type 2 diabetes. We examined whether quercetin could reverse chronic high glucose-induced oxidative stress and mitochondrial dysfunction. Following long-term high glucose treatment, complex I activity was significantly decreased in isolated mitochondria from HepG2 cells. Quercetin dose-dependently recovered complex I activity and lowered cellular ROS generation under both high and normal glucose conditions. Respirometry studies showed that quercetin could counteract the detrimental increase in i...
Subjects
Medical Subject Headings: heterocyclic compounds
free text keywords: Glycolysis, Oxidative stress, medicine.disease_cause, medicine, Inner mitochondrial membrane, Oxidative phosphorylation, NAD+ kinase, Mitochondrion, Insulin resistance, medicine.disease, Quercetin, chemistry.chemical_compound, chemistry, Biochemistry
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