Contribution of RSV to bronchiolitis and pneumonia-associated hospitalizations in English children, April 1995-March 1998.

Other literature type, Article English OPEN
Müller-Pebody, B. ; Edmunds, W. J. ; Zambon, M. C. ; Gay, N. J. ; Crowcroft, N. S. (2002)

Estimates of the number of hospitalizations attributable to specific pathogens are required to predict the potential impact of vaccination. All hospital admissions for lower respiratory tract infection (LRI) in children < 5 years in England in 1995-8 were reviewed. Most admissions (76.8%) were not associated with specific organisms. Seasonality in pathogens that cause bronchiolitis and pneumonia was used to predict the proportion of cases with unspecified aetiology attributable to different organisms using multiple linear regression. Of 12,298 admissions for LRI, 17.5% were due to RSV infection. An estimated 74.8% (95% CI, 72.0-77.7%) of 'unspecified bronchiolitis' admissions and 16.3% (95% CI, 13.7-18.8%) of unspecified pneumonia' admissions were RSV related. The total mean annual incidence of hospital admissions attributable to RSV is 28.3/1000 children < 1 year of age, and 1.3/1000 children 1-4 years old. The greater burden of RSV infection than indicated through discharge data is revealed through applying simple statistical methods.
  • References (17)
    17 references, page 1 of 2

    1. Groothuis JR, Gutierrez KM, Lauer BA. Respiratory syncytial virus infection in children with bronchopulmonary dysplasia. Pediatrics 1988 ; 82 : 199±203.

    2. Anderson LJ. Respiratory syncytial virus vaccines for otitis media. Vaccine 2001 ; 19 : 59±65.

    3. Falsey AR, Treanor JJ, Betts RF, Walsh EE. Viral respiratory infections in institutionalized elderly : clinical and epidemiological ®ndings. J Am Geriatrics Soc 2001 ; 40 : 115±9.

    4. Sorvillo FJ, Huie SF, Strassburg MA, Butsumyo A, Shandera WX, Fannin SL. An outbreak of respiratory syncytial virus pneumonia in a nursing home for the elderly. J Infect 1984 ; 9 : 252±6.

    5. Falsey AR, Walsh EE. Respiratory syncytial virus infections in adults. Clin Microbiol Rev 2000 ; 13 : 372±84.

    6. Dudas RA, Karron RA. Respiratory syncytial virus vaccines. Clin Microbiol Rev 1998 ; 11 : 430±9.

    7. Sims DG, Downham MA, McQuillin J, Gardner PS. Respiratory syncytial virus infection in north-east England. BMJ 1976 ; 2 : 1095±8.

    8. Thomas M, Bedford-Russell A, Sharland M. Hospitalization for RSV infection in ex-preterm infants ± implications for use of RSV immune globulin. Arch Dis Child 2000 ; 83 : 122±7.

    9. Clark SJ, Beresford MW, Subhedar NV, Shaw NJ. Respiratory syncytial virus infection in high risk infants and the potential impact of prophylaxis in a United Kingdom cohort. Arch Dis Child 2000 ; 83 : 313±6.

    10. Ryan MJ, Ramsay M, Brown D, Gay NJ, Farrington CP, Wall PG. Hopital admissions attributable to rotavirus infection in England and Wales. J Infect Dis 1996 ; 174 (Suppl. 1) : S12±8.

  • Metrics
    No metrics available
Share - Bookmark