Regulatory Mechanisms of Hsp90

Article English OPEN
Prodromou, Chrisostomos (2017)
  • Publisher: iMedPub
  • Journal: Biochemistry & molecular biology journal, volume 3, issue 1 (eissn: 2471-8084)
  • Related identifiers: pmc: PMC5346293, doi: 10.21767/2471-8084.100030
  • Subject: QP0501 | R | Hsp90 | Heat-shock response | Co-chaperones | HSF1 | Post-translational regulation | Chaperones | Article
    mesheuropmc: polycyclic compounds

The ability of Hsp90 to activate a disparate clientele implicates this chaperone in diverse biological processes. To accommodate such varied roles, Hsp90 requires a variety of regulatory mechanisms that are coordinated in order to modulate its activity appropriately. Amongst these, the master-regulator heat shock factor 1 (HSF1) is critically important in upregulating Hsp90 during stress, but is also responsible, through interaction with specific transcription factors (such as STAT1 and Strap/p300) for the integration of a variety of biological signals that ultimately modulate Hsp90 expression. Additionally, transcription factors, such as STAT1, STAT3 (including STAT1-STAT3 oligomers), NF-IL6, and NF-kB, are known to influence Hsp90 expression directly. Co-chaperones offer another mechanism for Hsp90 regulation, and these can modulate the chaperone cycle appropriately for specific clientele. Co-chaperones include those that deliver specific clients to Hsp90, and others that regulate the chaperone cycle for specific Hsp90-client complexes by modulating Hsp90s ATPase activity. Finally, post-translational modification (PTM) of Hsp90 and its co-chaperones helps too further regulate the variety of different Hsp90 complexes found in cells.
Share - Bookmark