publication . Article . 2016

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

Pallis, Monica; Burrows, Francis; Ryan, Jeremy; Grundy, Martin; Seedhouse, Claire; Abdul-Aziz, Amina; Montero, Joan; Letai, Anthony; Russell, Nigel;
  • Published: 15 Apr 2016
Abstract
// Monica Pallis 1 , Francis Burrows 2 , Jeremy Ryan 3 , Martin Grundy 1 , Claire Seedhouse 4 , Amina Abdul-Aziz 4 , Joan Montero 3 , Anthony Letai 3 , Nigel Russell 1, 4 1 Clinical Haematology, Nottingham University Hospitals, Nottingham, UK 2 Tragara Pharmaceuticals, Carlsbad, CA, USA 3 Department of Medical Oncology, Harvard Medical School, Boston, MA, USA 4 Department of Haematology, University of Nottingham, Nottingham, UK Correspondence to: Monica Pallis, e-mail: monica.pallis@nottingham.ac.uk Keywords: BAD, NOXA, TG02, ABT-199, AML Received: January 04, 2016      Accepted: March 28, 2016      Published: April 15, 2016 ABSTRACT Direct co-operation between ...
Subjects
free text keywords: AML, TG02, hemic and lymphatic diseases, BAD, biological phenomena, cell phenomena, and immunity, ABT-199, NOXA, Research Paper, Oncology, Kinase, Antagonist, Cytochrome c, biology.protein, biology, Hematology, medicine.medical_specialty, medicine, Drug action, Immunology, Apoptosis, Myeloid Cell Leukemia Sequence 1 Protein, Cytotoxic T cell, Cancer research, business.industry, business, Internal medicine, BAD, NOXA, TG02, ABT-199, AML
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