publication . Article . 2015

Mitochondria and the hallmarks of cancer

Evangelos Giampazolias; Stephen W.G. Tait;
Open Access English
  • Published: 25 Dec 2015
  • Publisher: Wiley-Blackwell Publishing Ltd.
  • Country: India
Abstract
Mitochondria have traditionally been viewed as the powerhouse of the cell, where they serve, amongst other functions, as a major source of ATP generation. More recently, mitochondria have also been shown to have active roles in a variety of other processes, including apoptotic cell death and inflammation. Here we review the various ways in which mitochondrial functions affect cancer. Although there are many diverse types of cancer, hallmarks have been defined that are applicable to most cancer types. We provide an overview of how mitochondrial functions affect some of these hallmarks, which include evasion of cell death, de-regulated bioenergetics, genome instab...
Subjects
free text keywords: Programmed cell death, The Hallmarks of Cancer, Genome, Metastasis, medicine.disease, medicine, Cell biology, Genome instability, Biology, Cancer, Mitochondrion, Cell, medicine.anatomical_structure
Related Organizations
32 references, page 1 of 3

1. Hanahan, D. & Weinberg, R. A. (2011) Hallmarks of cancer: the next generation, Cell. 144, 646-74.

2. Delbridge, A. R., Valente, L. J. & Strasser, A. (2012) The role of the apoptotic machinery in tumor suppression, Cold Spring Harbor perspectives in biology. 4.

3. Tait, S. W. & Green, D. R. (2013) Mitochondrial regulation of cell death, Cold Spring Harbor perspectives in biology. 5.

4. Tait, S. W. & Green, D. R. (2012) Mitochondria and cell signalling, Journal of cell science. 125, 807-15.

5. Lopez, J. & Tait, S. W. (2015) Mitochondrial apoptosis: killing cancer using the enemy within, British journal of cancer. 112, 957-62.

6. Lowe, S. W., Ruley, H. E., Jacks, T. & Housman, D. E. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents, Cell. 74, 957-67. [OpenAIRE]

7. Certo, M., Del Gaizo Moore, V., Nishino, M., Wei, G., Korsmeyer, S., Armstrong, S. A. & Letai, A. (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members, Cancer cell. 9, 351-65. 11. Cairns, R. A., Harris, I. S. & Mak, T. W. (2011) Regulation of cancer cell metabolism, Nature reviews Cancer. 11, 85-95. [OpenAIRE]

18. Picaud, S., Kavanagh, K. L., Yue, W. W., Lee, W. H., Muller-Knapp, S., Gileadi, O., Sacchettini, J. & Oppermann, U. (2011) Structural basis of fumarate hydratase deficiency, Journal of inherited metabolic disease. 34, 671-6.

19. O'Flaherty, L., Adam, J., Heather, L. C., Zhdanov, A. V., Chung, Y. L., Miranda, M. X., Croft, J., Olpin, S., Clarke, K., Pugh, C. W., Griffiths, J., Papkovsky, D., Ashrafian, H., Ratcliffe, P. J. & Pollard, P. J. (2010) Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism, Human molecular genetics. 19, 3844-51.

20. Frezza, C., Zheng, L., Folger, O., Rajagopalan, K. N., MacKenzie, E. D., Jerby, L., Micaroni, M., Chaneton, B., Adam, J., Hedley, A., Kalna, G., Tomlinson, I. P., Pollard, P. J., Watson, D. G., Deberardinis, R. J., Shlomi, T., Ruppin, E. & Gottlieb, E. (2011) Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase, Nature. 477, 225-8.

21. Bardella, C., Pollard, P. J. & Tomlinson, I. (2011) SDH mutations in cancer, Biochimica et biophysica acta. 1807, 1432-43. [OpenAIRE]

22. Muller, P. A. & Vousden, K. H. (2013) p53 mutations in cancer, Nature cell biology. 15, 2-8.

23. Kruiswijk, F., Labuschagne, C. F. & Vousden, K. H. (2015) p53 in survival, death and metabolic health: a lifeguard with a licence to kill, Nature reviews Molecular cell biology. 16, 393-405. [OpenAIRE]

24. Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J. & Thompson, C. B. (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint, Molecular cell. 18, 283-93.

25. Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N., Nakano, K., Bartrons, R., Gottlieb, E. & Vousden, K. H. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis, Cell. 126, 107-20. [OpenAIRE]

32 references, page 1 of 3
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