publication . Article . Other literature type . 2015

Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell–Mediated Antitumor Immunity

Brentville, Victoria A.; Metheringham, Rachael L.; Gunn, Barbara; Symonds, Peter; Daniels, Ian; Gijon, Mohamed; Cook, Katherine; Xue, Wei; Durrant, Lindy;
Open Access
  • Published: 30 Dec 2015 Journal: Cancer Research, volume 76, pages 548-560 (issn: 0008-5472, eissn: 1538-7445, Copyright policy)
  • Publisher: American Association for Cancer Research (AACR)
  • Country: Italy
Abstract
Stressful conditions in the harsh tumor microenvironment induce autophagy in cancer cells as a mechanism to promote their survival. However, autophagy also causes post-translational modification of proteins that are recognized by the immune system. In particular, modified self-antigens can trigger CD4(+) T-cell responses that might be exploited to boost antitumor immune defenses. In this study, we investigated the ability of CD4 cells to target tumor-specific self-antigens modified by citrullination, which converts arginine residues in proteins to citrulline. Focusing on the intermediate filament protein vimentin, which is frequently citrullinated in cells durin...
Subjects
free text keywords: Immunology, Citrullination, Molecular biology, Tumor microenvironment, Biology, Vimentin, biology.protein, CD8, Granzyme, Cancer research, Immune system, Major histocompatibility complex, Cancer cell
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