Neural correlates of visuospatial working memory in the 'at-risk mental state'

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Broome, M. R. ; Fusar-Poli, P. ; Matthiasson, P. ; Woolley, J. B. ; Valmaggia, L. ; Johns, L. C. ; Tabraham, P. ; Bramon, E. ; Williams, S. C. R. ; Brammer, M. J. ; Chitnis, X. ; Zelaya, F. ; McGuire, P. K. (2010)
  • Publisher: Cambridge University Press
  • Related identifiers: doi: 10.1017/S0033291710000280, doi: 10.1017/S0033291710000280
  • Subject: RC | /dk/atira/pure/subjectarea/asjc/2700/2738 | Applied Psychology | /dk/atira/pure/subjectarea/asjc/3200/3202 | Psychiatry and Mental health
    mesheuropmc: behavioral disciplines and activities

Background. Impaired spatial working memory (SWM) is a robust feature of schizophrenia and has been linked to\ud the risk of developing psychosis in people with an at-risk mental state (ARMS). We used functional magnetic\ud resonance imaging (fMRI) to examine the neural substrate of SWM in the ARMS and in patients who had just\ud developed schizophrenia.\ud Method. fMRI was used to study 17 patients with an ARMS, 10 patients with a first episode of psychosis and 15 agematched\ud healthy comparison subjects. The blood oxygen level-dependent (BOLD) response was measured while\ud subjects performed an object–location paired-associate memory task, with experimental manipulation of mnemonic\ud load.\ud Results. In all groups, increasing mnemonic load was associated with activation in the medial frontal and medial\ud posterior parietal cortex. Significant between-group differences in activation were evident in a cluster spanning the\ud medial frontal cortex and right precuneus, with the ARMS groups showing less activation than controls but greater\ud activation than first-episode psychosis (FEP) patients. These group differences were more evident at the most\ud demanding levels of the task than at the easy level. In all groups, task performance improved with repetition of the\ud conditions. However, there was a significant group difference in the response of the right precuneus across repeated\ud trials, with an attenuation of activation in controls but increased activation in FEP and little change in the ARMS.\ud Conclusions. Abnormal neural activity in the medial frontal cortex and posterior parietal cortex during an SWM task\ud may be a neural correlate of increased vulnerability to psychosis.
  • References (48)
    48 references, page 1 of 5

    McGuire P (2007). Neurofunctional correlates of vulnerability to psychosis : a systematic review and metaanalysis. Neuroscience and Biobehavioral Reviews 31, 465-484.

    Glahn DC, Ragland JD, Abramoff A, Barrett J, Laird AR, Bearden CE, Velligan DI (2005). Beyond hypofrontality : a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Human Brain Mapping 25, 60-69.

    Goldstein LH, Canavan AG, Polkey CE (1988). Verbal and abstract designs paired associate learning after unilateral temporal lobectomy. Cortex 24, 41-52.

    Gould RL, Brown RG, Owen AM, ffytche DH, Howard RJ (2003). fMRI BOLD response to increasing task difficulty during successful paired associates learning. NeuroImage 20, 1006-1019.

    Honey GD, Sharma T, Suckling J, Giampietro V, Soni W, Williams SC, Bullmore ET (2003). The functional neuroanatomy of schizophrenic subsyndromes. Psychological Medicine 33, 1007-1018.

    Joyce E, Huddy V (2004). Defining the cognitive impairment in schizophrenia. Psychological Medicine 34, 1151-1155.

    Kay SR (1990). Positive-negative symptom assessment in schizophrenia : psychometric issues and scale comparison. Psychiatry Quarterly 61, 163-178.

    Keshavan MS, Diwadkar VA, Spencer SM, Harenski KA, Luna B, Sweeney JA (2002). A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents. Progress in Neuropsychopharmacology and Biological Psychiatry 26, 1143-1149.

    Krause BJ, Schmidt D, Mottaghy FM, Taylor J, Halsband U, Herzog H, Tellmann L, Muller-Gartner HW (1999). Episodic retrieval activates the precuneus irrespective of the imagery content of word pair associates. A PET study. Brain 122, 255-263.

    Kuperberg GR, Broome MR, McGuire PK, David AS, Eddy M, Ozawa F, Goff D, West WC, Williams SC, van der Kouwe AJ, Salat DH, Dale AM, Fischl B (2003). Regionally localized thinning of the cerebral cortex in schizophrenia. Archives of General Psychiatry 60, 878-888.

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