Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.

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Tomlinson, JW; Finney, J; Gay, C; Hughes, BA; Hughes, SV; Stewart, PM;
(2008)
  • Publisher: American Diabetes Association
  • Subject:
    mesheuropmc: hormones, hormone substitutes, and hormone antagonists

OBJECTIVE: The precise molecular mechanisms contributing to the development of insulin resistance, impaired glucose tolerance (IGT), and type 2 diabetes are largely unknown. Altered endogenous glucocorticoid metabolism, including 11beta-hydroxysteroid dehydrogenase type... View more
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