Behavioural analysis of transgenic mice overexpressing gamma-synuclein

Doctoral thesis English OPEN
Salem, Hatem
  • Subject: QH301
    mesheuropmc: nervous system diseases | nervous system | animal diseases | mental disorders

The alpha-synucleinopathies is a diverse group of diseases characterised by\ud malfunctioning of alpha-synuclein protein. Parkinson’s disease is the most common\ud of all alpha-synucleinopathies.\ud Intracellular inclusions, like Lewy bodies and certain other abnormal structures are\ud the pathological hallmarks of this group of neurodegenerative diseases. The main\ud protein component of these structures is alpha-synuclien.\ud Alpha-synuclein is a member of the synuclein family, which consists of 3 closely\ud related proteins, alpha-, beta- and gamma-synucleins. Alpha-synuclein is more\ud extensively studied because of its direct involvement in human diseases, while our\ud knowledge about two other family members is very limited. Neither beta-synuclein,\ud nor gamma-synuclein is a component of Lewy bodies and other pathological\ud structures typical for neurodegenerative diseases.
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