The beta-subunit of human chorionic gonadotrophin exists as a homodimer

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Butler, Stephen A.; Laidler, Paul; Porter, J. R.; Kicman, Andrew T.; Chard, Tim; Cowan, David A.; Iles, Ray K.;
  • Publisher: Journal of Endocrinology

The free beta-subunit of human chorionic gonadotrophin (hCGbeta) is well recognised as a product of many epithelial tumours. Recently, it has been shown that this ectopic production may have a functional relationship to tumour growth. The growth-promoting activity of hC... View more
  • References (43)
    43 references, page 1 of 5

    Albini A, Paglieri I, Orengo G, Carlone S, Aluigi MG, DeMarchi R, Matteucci C, Mantovani A, Carozzi F, Donini S & Benelli R 1997 The â-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalised Kaposi's sarcoma cell line. AIDS 11 713-721.

    Amit AG, Mariuzza RA, Phillips SEV & Poljak RJ 1986 Three-dimensional structure of antigen-antibody complex at 2·8 Ar resolution. Science 233 747-753.

    Bell JJ, Canfield RE & Sciarra JJ 1969 Purification of and characterization of human chorionic gonadotropin. Endocrinology 84 298-307.

    Blithe DL 1994 Structure and function of the gonadotropin free alpha molecule of pregnancy. In Glycoprotein Hormones: Structure, Function, Clinical Implications, pp 156-166. Eds JW Lustbader, D Puett & RW Ruddon. New York: Springer Verlag.

    Blithe DL, Richards RG & Skarulis MC 1991 Free á molecules from pregnancy stimulate secretion of prolactin from human decidual cells: a novel function for free á in pregnancy. Endocrinology 129 2257-2259.

    Burton RD, Watson CH, Eyler JR, Lang GL, Powell DH & Avery MY 1997 Proton aYnities of eight matrices used for matrix-assisted laser desorption/ionization. Rapid Communications in Mass Spectrometry 11 443-446.

    Butt WR, Chard T & Iles RK 1994 Hormones of the placenta: hCG and hPL. In Marshalls Physiology of Reproduction, edn 4, vol 3 Pregnancy and Lactation, pp 461-534. Ed. GE Lamming. London: Chapman & Hall.

    Canfield RE, Morgan RJ, Kammerman S, Bell JJ & Agosto GM 1971 Studies of human chorionic gonadotropin. Recent Progress in Hormone Research 27 121-164.

    Cohen LRH, Strupat K & Hillenkamp F 1997 Analysis of quaternary protein ensembles by matrix assisted laser desorption/ionization mass spectrometry. Journal of the American Society for Mass Spectrometry 8 1046-1052.

    Cuckle HS, Iles RK & Chard T 1994 Urinary â-core human chorionic gonadotrophin: a new approach to Down's syndrome screening. Prenatal Diagnosis 14 953-958.

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