Maternal obesity has little effect on the immediate offspring but impacts on the next generation

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King, Vicky; Dakin, Rachel S.; Liu, Lincoln; Hadoke, Patrick W. F.; Walker, Brian R.; Seckl, Jonathan R.; Norman, Jane E.; Drake, Amanda J.;
  • Publisher: Endocrine Society
  • Subject: QP

Maternal obesity during pregnancy has been linked to an increased risk of obesity and cardiometabolic disease in the offspring, a phenomenon attributed to developmental programming. Programming effects may be transmissible across generations through both maternal and pa... View more
  • References (65)
    65 references, page 1 of 7

    1. Haslam DW, James WP. Obesity. Lancet. 2005;366:1197-1209.

    2. Warner MJ, Ozanne SE. Mechanisms involved in the developmental programming of adulthood disease. Biochem J. 2010;427:333-347.

    3. Garbaciak JA Jr, Richter M, Miller S, Barton JJ. Maternal weight and pregnancy complications. Am J Obstet Gynecol. 1985;152: 238 -245.

    4. Catalano PM, McIntyre HD, Cruickshank JK, et al; HAPO Study Cooperative Research Group The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes. Diabetes Care. 2012;35:780 -786.

    5. Drake AJ, Reynolds RM. Impact of maternal obesity on offspring obesity and cardiometabolic disease risk. Reproduction. 2010;140: 387-398.

    6. Robinson SM, Godfrey KM. Feeding practices in pregnancy and infancy: relationship with the development of overweight and obesity in childhood. Int J Obes. 2008;32:S4 -S10.

    7. Li M, Sloboda D, Vickers M. Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models. Exp Diabetes Res. 2011;2011:592408.

    8. Armitage JA, Taylor PD, Poston L. Experimental models of developmental programming: consequences of exposure to an energy rich diet during development. Journal of Physiology. 2005;565:3- 8.

    9. Ainge H, Thompson C, Ozanne SE, Rooney KB. A systematic review on animal models of maternal high fat feeding and offspring glycaemic control. Int J Obes (Lond). 2011;35:325-335.

    10. Oben JA, Mouralidarane A, Samuelsson AM, et al. Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol. 2010;52: 913-920.

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