Novel hybrids of natural β-elemene bearing isopropanolamine moieties: synthesis, enhanced anticancer profile, and improved aqueous solubility

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Chen, Jichao.; Wang, Tianyu.; Xu, Shengtao.; Aijun, Lin.; Yao, Hequan.; Xie, Weijia.; Zhu, Zheying.; Xu, Jinyi.;
  • Publisher: Elsevier
  • Subject: β-Elemene | Isopropanolamine | Dimer | Antitumor activity | Aqueous solubility

A series of novel β-elemene isopropanolamine derivatives were synthesized and evaluated for their antitumor activity. The results indicated that all of the compounds showed stronger antiproliferative activities than β-elemene as well as improved aqueous solubility. In p... View more
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