publication . Thesis

Synthesis of a molecularly tethered dual function germinant and antimicrobial agent

Hird, Matthew;
Open Access English
  • Country: United Kingdom
Abstract
Clostridium difficile (C. difficile) bacteria are the leading cause of nosocomial diarrhoea in the UK. The problem with the removal of C. difficile from hospitals is that it can sporulate and therefore be difficult to remove/kill using conventional methods. The spores enter the body via the faecal-oral route and in the presence of germinants (taurocholate), germinate into vegetative cells in the intestine, cause infection and produce symptoms via the release of two main toxins. The project’s aim was to produce polymeric steroid-based antimicrobial materials which will be able to germinate spores and then destroy the resulting vegetative cells. Deoxycholic acid, ...
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