Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes

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Sutherland, CJ; Alloueche, A; Curtis, J; Drakeley, CJ; Ord, R; Duraisingh, M; Greenwood, BM; Pinder, M; Warhurst, D; Targett, GA;
(2002)
  • Publisher: American Society of Tropical Medicine and Hygiene
  • Subject:
    mesheuropmc: parasitic diseases

Polymorphisms in two genes of Plasmodium falciparum (P. falciparum multidrug resistance 1 [pfmdr1] and P. falciparum chloroquine [CQ] resistance transporter [pfcrt]) are associated with CQ treatment failure. We found significant linkage disequilibrium between these loci... View more
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