Magnetic Nanoparticle-Mediated Gene Delivery to Two- and Three-Dimensional Neural Stem Cell Cultures: Magnet-Assisted Transfection and Multifection Approaches to Enhance Outcomes.

Part of book or chapter of book English OPEN
Pickard, MR; Adams, CF; Chari, DM;
(2017)
  • Publisher: Wiley
  • Identifiers: doi: 10.1002/9780470151808
  • Subject: Q1 | gene delivery | neural stem cells | transplantation | magnetic nanoparticles | magnetofection | R1

Neural stem cells (NSCs) have high translational potential in transplantation therapies for neural repair. Enhancement of their therapeutic capacity by genetic engineering is an important goal for regenerative neurology. Magnetic nanoparticles (MNPs) are major non-viral... View more
  • References (18)
    18 references, page 1 of 2

    Berman, S.M.C., Walczak, P., Bulte, J.W.M. 2011. Tracking stem cells using magnetic nanoparticles. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 3: 343-355. doi:10.1002/wnan.140

    Conti, L. and Cattaneo, E. 2010. Neural stem cell systems: physiological players or in vitro entities? Nat. Rev. Neurosci. 11: 176-87. doi:10.1038/nrn2761

    Elsabahy, M., Nazarali, A. and Foldvari, M. 2011. Non-viral nucleic acid delivery: key challenges and future directions. Curr. Drug Deliv. 8: 235-244. doi:10.2174/156720111795256174

    Fernandes, A.R. and Chari, D.M. 2016a. Part I: Minicircle vector technology limits DNA size restrictions on ex vivo gene delivery using nanoparticle vectors: Overcoming a translational barrier in neural stem cell therapy. J. Control. Release. doi:10.1016/j.jconrel.2016.06.024

    Fernandes, A.R. and Chari, D.M. 2016b. Part II: Functional delivery of a neurotherapeutic gene to neural stem cells using minicircle DNA and nanoparticles: Translational advantages for Regenerative Neurology. J. Control. Release. doi:10.1016/j.jconrel.2016.06.039

    de Filippis, L. 2011. Neural stem cell-mediated therapy for rare brain diseases: perspectives in the near future for LSDs and MNDs. Histol. Histopathol., 26: 1093-109. doi:10.14670/HH26.1093

    Jensen, J. and Parmar, M. 2006. Strengths and limitations of the neurosphere culture system. Mol. Neurobiol., 34: 153-161. doi:10.1385/MN:34:3:153

    Kim, S.U. and de Vellis, J. 2009. Stem cell-based cell therapy in neurological diseases: a review. J. Neurosci. Res., 87: 2183-2200. doi:10.1002/jnr.22054.

    Meng, X.-L., Shen, J.-S., Ohashi, T., Maeda, H., Kim, S.U. and Eto, Y. 2003. Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse. J. Neurosci. Res., 74: 266-77. doi:10.1002/jnr.10764

    Mintzer, M.A. and Simanek, E.E. 2009. Nonviral vectors for gene delivery. Chem. Rev., 109: 259- 302. doi:10.1021/cr800409e

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