Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies

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Joice, Shannon L.; Mydeen, Firdau; Couraud, Pierre-Olivier; Weksler, Babette B.; Romero, Ignacio A.; Fraser, Paul A.; Easton, Alexander S.;

The blood-brain barrier (BBB) restricts solute permeability across healthy cerebral endothelial cells. However, during inflammation, permeability is increased and can lead to deleterious cerebral edema. Neutrophils are early cellular participants in acute inflammation, ... View more
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    Shannon L Joice1, Firdaus Mydeen1, Pierre-Olivier Couraud4,5,6,7, Babette B Weksler5,8, Ignacio A Romero9, Paul A Fraser10 & Alexander S Easton1,2,3. T IP R

    1. Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. C

    2. Department of Microbiology and Immunology, Dalhousie SUniversity, Halifax, Nova Scotia, Canada. U

    3. Division of Neurosurgery, Department of Surgery, DNalhousie University, Halifax, Nova Scotia, Canada. MA

    4. Department of Cell Biology, Institut Cochin, Paris, France.

    5. Inserm, U567, Paris, France. ED

    6. CNRS, UMR 8104, Paris, France. T

    7. Université Paris 5, Faculté de MPédecine René Descartes, UM3, Paris, France. E

    8. Department of Medicine, Weill Medical College, New York, New York, USA. C

    9. Department of BiologiCcal Sciences, The Open University, Milton Keynes, UK.

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