publication . Article . 2018

Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders

Boldrini, Paolo; Fusco, Antonella; Nicoletti, Ferdinando; Badiani, Aldo; Saso, Luciano;
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  • Published: 01 Jun 2018 Journal: Current Drug Targets, volume 19, pages 636-650 (issn: 1389-4501, Copyright policy)
  • Publisher: Bentham Science Publishers Ltd.
  • Country: United Kingdom
Abstract
It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. In this review we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy...
Subjects
free text keywords: Central nervous system, medicine.anatomical_structure, medicine, business.industry, business, Psychiatry, medicine.medical_specialty, Bioinformatics, Pharmacology, Anxiety, medicine.symptom, Diabetes mellitus, medicine.disease, Oxidative stress, medicine.disease_cause
64 references, page 1 of 5

Baxter AJ, Scott KM, Vos T, et al. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med 2013; 43: 897-910.

Epidemiology of anxiety disorders. Curr Top Behav Neurosci 2010; 2: 21-35.

Home | APA DSM5http://www.dsm5.org/Pages/Default.aspx (accessed 7 March 2016).

Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 593-602.

Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci 2015; 17: 327-335. [OpenAIRE]

Alonso J, Angermeyer MC, Bernert S, et al. 12- Month comorbidity patterns and associated factors in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl 2004; 28-37.

Smith KJ, Béland M, Clyde M, et al. Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res 2013; 74: 89- 99.

PloS One 2013; 8: e60532.

[9] Ittermann T, Völzke H, Baumeister SE, et al. Diagnosed thyroid disorders are associated with depression and anxiety. Soc Psychiatry Psychiatr Epidemiol 2015; 50: 1417-1425. [OpenAIRE]

[10] Celano CM, Millstein RA, Bedoya CA, et al. Association between anxiety and mortality in patients with coronary artery disease: A metaanalysis. Am Heart J 2015; 170: 1105-1115. [OpenAIRE]

[11] Etkin A, Prater KE, Schatzberg AF, et al. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 2009; 66: 1361-1372. [OpenAIRE]

[12] Guney E, Fatih Ceylan M, Tektas A, et al. Oxidative stress in children and adolescents with anxiety disorders. J Affect Disord 2014; 156: 62- 66.

[13] Hovatta I, Juhila J, Donner J. Oxidative stress in anxiety and comorbid disorders. Neurosci Res 2010; 68: 261-275. [OpenAIRE]

[14] West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol 2011; 11: 389-402.

[15] Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol 2007; 47: 143-183. [OpenAIRE]

64 references, page 1 of 5
Abstract
It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. In this review we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy...
Subjects
free text keywords: Central nervous system, medicine.anatomical_structure, medicine, business.industry, business, Psychiatry, medicine.medical_specialty, Bioinformatics, Pharmacology, Anxiety, medicine.symptom, Diabetes mellitus, medicine.disease, Oxidative stress, medicine.disease_cause
64 references, page 1 of 5

Baxter AJ, Scott KM, Vos T, et al. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med 2013; 43: 897-910.

Epidemiology of anxiety disorders. Curr Top Behav Neurosci 2010; 2: 21-35.

Home | APA DSM5http://www.dsm5.org/Pages/Default.aspx (accessed 7 March 2016).

Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 593-602.

Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci 2015; 17: 327-335. [OpenAIRE]

Alonso J, Angermeyer MC, Bernert S, et al. 12- Month comorbidity patterns and associated factors in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl 2004; 28-37.

Smith KJ, Béland M, Clyde M, et al. Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res 2013; 74: 89- 99.

PloS One 2013; 8: e60532.

[9] Ittermann T, Völzke H, Baumeister SE, et al. Diagnosed thyroid disorders are associated with depression and anxiety. Soc Psychiatry Psychiatr Epidemiol 2015; 50: 1417-1425. [OpenAIRE]

[10] Celano CM, Millstein RA, Bedoya CA, et al. Association between anxiety and mortality in patients with coronary artery disease: A metaanalysis. Am Heart J 2015; 170: 1105-1115. [OpenAIRE]

[11] Etkin A, Prater KE, Schatzberg AF, et al. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry 2009; 66: 1361-1372. [OpenAIRE]

[12] Guney E, Fatih Ceylan M, Tektas A, et al. Oxidative stress in children and adolescents with anxiety disorders. J Affect Disord 2014; 156: 62- 66.

[13] Hovatta I, Juhila J, Donner J. Oxidative stress in anxiety and comorbid disorders. Neurosci Res 2010; 68: 261-275. [OpenAIRE]

[14] West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol 2011; 11: 389-402.

[15] Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annu Rev Pharmacol Toxicol 2007; 47: 143-183. [OpenAIRE]

64 references, page 1 of 5
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