Basic science behind the cardiovascular benefits of exercise

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Wilson, MG ; Ellison, GM ; Cable, NT

Cardiorespiratory fitness is a strong predictor of cardiovascular (CV) disease and all-cause mortality, with increases in cardiorespiratory fitness associated with corresponding decreases in CV disease risk. The effects of exercise upon the myocardium and vascular system are dependent upon the frequency, intensity and duration of the exercise itself. Following a prolonged period (≥6 months) of regular intensive exercise in previously untrained individuals, resting and submaximal exercising heart rates are typically 5–20 beats lower, with an increase in stroke volume of ∼20% and enhanced myocardial contractility. Structurally, all four heart chambers increase in volume with mild increases in wall thickness, resulting in greater cardiac mass due to increased myocardial cell size. With this in mind, the present paper aims to review the basic science behind the CV benefits of exercise. Attention will be paid to understanding (1) the relationship between exercise and cardiac remodelling; (2) the cardiac cellular and molecular adaptations in response to exercise, including the examination of molecular mechanisms of physiological cardiac growth and applying these mechanisms to identify new therapeutic targets to prevent or reverse pathological remodelling and heart failure; and (3) vascular adaptations in response to exercise. Finally, this review will briefly examine how to optimise the CV benefits of exercise by considering how much and how intense exercise should be.
  • References (15)
    15 references, page 1 of 2

    Blair SN, Kohl HW, 3rd, Paffenbarger RS, Jr., et al. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 1989;262(17):2395- 401.

    Kodama S, Saito K, Tanaka S, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a metaanalysis. JAMA 2009;301(19):2024-35.

    Lee DC, Sui X, Artero EG, et al. Long-term effects of changes in cardiorespiratory fitness and body mass index on all-cause and cardiovascular disease mortality in men: the Aerobics Center Longitudinal Study. Circulation 2011;124(23):2483-90.

    Marijon E, Tafflet M, Antero-Jacquemin J, et al. Mortality of French participants in the Tour de France (1947-2012). Eur Heart J 2013;34(40):3145-50.

    Swedish National Institute of Public Health. Physical Activity in the Prevention and Treatment of Disease. 2010. Sweden. http://www.fyss.se/wpcontent/uploads/2011/02/fyss_2010_english.pdf Arbab-Zadeh A, Perhonen M, Howden E, et al. Cardiac Remodeling in Response to 1 Year of Intensive Endurance Training. Circulation 2014.

    Utomi V, Oxborough D, Whyte GP, et al. Systematic review and meta-analysis of training mode, imaging modality and body size influences on the morphology and function of the male athlete's heart. Heart 2013;99(23):1727-33.

    Scharhag J, Thunenkotter T, Urhausen A, et al. Echocardiography of the right ventricle in athlete's heart and hearts of normal size compared to magnetic resonance imaging: which measurements should be applied in athletes? Int J Sports Med 2010;31(1):58-64.

    Wilson M, O'Hanlon R, Prasad S, et al. Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. J Appl Physiol 2011;110(6):1622-6.

    Pelliccia A, Maron BJ, Spataro A, et al. The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. N Engl J Med 1991;324(5):295-301.

    Whyte GP, George K, Sharma S, et al. The upper limit of physiological cardiac hypertrophy in elite male and female athletes: the British experience. Eur J Appl Physiol 2004;92(4-5):592-7.

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