Thrombosis prevention trial: compliance with warfarin treatment and investigation of a retained effect.

Article English OPEN
Rudnicka, AR; Ashby, D; Brennan, P; Meade, T;
  • Publisher: American Medical Association
  • Subject:
    mesheuropmc: cardiovascular diseases

BACKGROUND: The Thrombosis Prevention Trial was a primary prevention factorial trial that reported a reduction in the risk of coronary heart disease (CHD) with warfarin and/or aspirin. This article examines compliance (duration of treatment) with warfarin treatment and ... View more
  • References (8)

    1. The Medical Research Council's General Practice Research Framework. Thrombosis Prevention Trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. Lancet. 1998;351:233-241.

    2. The Post Coronary Artery Bypass Graft Trial Investigators. The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts. N Engl J Med. 1997;336:153-162.

    3. Knatterud GL, Rosenberg Y, Campeau L, et al. Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Circulation. 2000;102:157-165.

    4. Knottenbelt C, Brennan PJ, Meade TW. Antithrombotic treatment and the incidence of angina pectoris. Arch Intern Med. 2002;162:881-886.

    5. Meade TW, Mellows S, Brozovic M, et al. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet. 1986; 2:533-537.

    6. Robins JM, Tsiatis AA. Correcting for non-compliance in randomized trials using a rank preserving structural failure time model. Comm Stat A. 1991;20:2609- 2631.

    7. Korhonen PA, Laird NM, Palmgren J. Correcting for non-compliance in randomized trials: an application to the ATBC study. Stat Med. 1999;18:2879-2897.

    8. Born GVR. Effects of aspirin and warfarin on fatal and non-fatal heart attacks [letter]. Lancet. 1999;354:1472.

  • Metrics
Share - Bookmark