Interleukin 9 fate reporter reveals induction of innate IL-9 response in lung inflammation

Article, Unknown English OPEN
Stockinger , Brigitta B ; Hirota , Keiji ; Stieglitz , Benjamin ; Van Snick , Jacques ; Tolaini , Mauro ; Sparwasser , Tim ; Helmby , Helena ; Lahl , Katharina ; Wilhelm , Christoph (2011)
  • Publisher: Nature Publishing Group
  • Journal: Nature immunology, volume 12, issue 11, pages 1,071-1,077 (issn: 1529-2908, eissn: 1529-2916)
  • Related identifiers: pmc: PMC3198843, doi: 10.1038/ni.2133
  • Subject: Innate immunity | Inflammation | Allergy | Cytokines | [ SDV.IMM ] Life Sciences [q-bio]/Immunology | Article

Abstract Interleukin 9 (IL-9) is a cytokine implicated in lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to fate map cells that have activated IL-9. We show that during papain-induced lung inflammation IL-9 production was largely restricted to innate lymphoid cells (ILC). IL-9 production by ILC was dependent on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies substantially reduced IL-13 and IL-5, suggesting that ILC provide the missing link between the well-established functions of IL-9 on the regulation of TH2 cytokines and responses. bstocki@nimr.mrc.ac.uk (Stockinger, Brigitta B) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Stockinger, Brigitta B) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Hirota, Keiji) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Stieglitz, Benjamin) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (van Snick, Jacques) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Tolaini, Mauro) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Sparwasser, Tim) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Helmby, Helena) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Lahl, Katharina) Division of Molecular Immunology - The Ridgeway, Mill Hill, London, United Kingdom NW7 1AA--> - UNITED KINGDOM (Wilhelm, Christoph) UNITED KINGDOM Accepted: 2011-09-06 Received: 2011-04-26 Revised: 2011-09-06
Share - Bookmark