publication . Article . Other literature type . 2017

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

Dumas, Marc-Emmanuel; Rothwell, Alice R.; Hoyles, Lesley; Aranias, Thomas; Chilloux, Julien; Calderari, Sophie; Noll, Elisa M.; Péan, Noémie; Boulangé, Claire L.; Blancher, Christine; ...
Open Access English
  • Published: 05 Jul 2017
  • Publisher: HAL CCSD
Dumas et al. study the metabolic and behavioral phenotypic heterogeneity induced by a high-fat diet intervention in an isogenic mouse population model. Using 1H-NMR spectroscopy, they identify pre-interventional urinary metabolic signatures (including microbial-host co-metabolites) predicting future phenotypic heterogeneity. In particular, TMAO corrects endoplasmic reticulum stress and glucose tolerance.
free text keywords: TMAO, anxiety, endoplasmic reticulum stress, impaired glucose tolerance, insulin secretion, metabolome, microbiome, natural phenotypic variation, obesity, transcriptome, trimethylamine-N-oxide, anxiety disorder, anxiete, obésité, sécrétion d'insuline, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Science & Technology, Life Sciences & Biomedicine, Cell Biology, HUMAN GUT MICROBIOME, HIGH-FAT DIET, ENDOPLASMIC-RETICULUM STRESS, CONTAINING MONOOXYGENASE 3, UNFOLDED PROTEIN RESPONSE, INSULIN-RESISTANT MICE, L-CARNITINE, BACTERIAL METABOLITES, CHEMICAL CHAPERONES, Article, Biologie du développement, Development Biology, TMAO;anxiety;endoplasmic reticulum stress;impaired glucose tolerance;insulin secretion;metabolome;microbiome;natural phenotypic variation;obesity;transcriptome;trimethylamine-N-oxide, Biology (General), QH301-705.5, General Biochemistry, Genetics and Molecular Biology, Homeostasis, Internal medicine, medicine.medical_specialty, medicine, Trimethylamine N-oxide, chemistry.chemical_compound, chemistry, Population, education.field_of_study, education, Biology, Endocrinology, Genetic heterogeneity, medicine.disease, Lipogenesis
81 references, page 1 of 6

Akerfeldt, M.C., Howes, J., Chan, J.Y., Stevens, V.A., Boubenna, N., McGuire, H.M., King, C., Biden, T.J., and Laybutt, D.R. (2008). Cytokine-induced betacell death is independent of endoplasmic reticulum stress signaling. Diabetes 57, 3034-3044. [OpenAIRE]

Al-Waiz, M., Ayesh, R., Mitchell, S.C., Idle, J.R., and Smith, R.L. (1987). Disclosure of the metabolic retroversion of trimethylamine N-oxide in humans: a pharmacogenetic approach. Clin. Pharmacol. Ther. 42, 608-612. [OpenAIRE]

al-Waiz, M., Mikov, M., Mitchell, S.C., and Smith, R.L. (1992). The exogenous origin of trimethylamine in the mouse. Metabolism 41, 135-136. [OpenAIRE]

Bai, C., Biwersi, J., Verkman, A.S.A., and Matthay, M.A.M. (1998). A mouse model to test the in vivo efficacy of chemical chaperones. J. Pharmacol. Toxicol. Methods 40, 39-45.

Basseri, S., Lhota´ k, S., Sharma, A.M., and Austin, R.C. (2009). The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response. J. Lipid Res. 50, 2486-2501. [OpenAIRE]

Bennett, B.J., de Aguiar Vallim, T.Q., Wang, Z., Shih, D.M., Meng, Y., Gregory, J., Allayee, H., Lee, R., Graham, M., Crooke, R., et al. (2013). TrimethylamineN-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 17, 49-60.

Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K.D., et al. (2011). ). The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. [OpenAIRE]

Gastroenterology 141, 599-609, 609.e1-609.e3.

Blaise, B.J., Giacomotto, J., Elena, B., Dumas, M.-E., Toulhoat, P., Se´ galat, L., and Emsley, L. (2007). Metabotyping of Caenorhabditis elegans reveals latent phenotypes. Proc. Natl. Acad. Sci. USA 104, 19808-19812. [OpenAIRE]

(2009). Statistical recoupling prior to significance testing in nuclear magnetic resonance based metabonomics. Anal. Chem. 81, 6242-6251.

Bravo, J.A., Forsythe, P., Chew, M.V., Escaravage, E., Savignac, H.M., Dinan, T.G., Bienenstock, J., and Cryan, J.F. (2011). Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. USA 108, 16050-16055. [OpenAIRE]

Burcelin, R., Crivelli, V., Dacosta, A., Roy-Tirelli, A., and Thorens, B. (2002).

Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. Am.

J. Physiol. Endocrinol. Metab. 282, E834-E842.

Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A.M., Fava, F., Tuohy, K.M., Chabo, C., et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772.

81 references, page 1 of 6
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