publication . Article . Other literature type . 2017

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

Dumas, Marc-Emmanuel; Rothwell, Alice R.; Hoyles, Lesley; Aranias, Thomas; Chilloux, Julien; Calderari, Sophie; Noll, Elisa M.; Péan, Noémie; Boulangé, Claire L.; Blancher, Christine; ...
Open Access English
  • Published: 05 Jul 2017
  • Publisher: HAL CCSD
Abstract
Dumas et al. study the metabolic and behavioral phenotypic heterogeneity induced by a high-fat diet intervention in an isogenic mouse population model. Using 1H-NMR spectroscopy, they identify pre-interventional urinary metabolic signatures (including microbial-host co-metabolites) predicting future phenotypic heterogeneity. In particular, TMAO corrects endoplasmic reticulum stress and glucose tolerance.
Subjects
free text keywords: TMAO, anxiety, endoplasmic reticulum stress, impaired glucose tolerance, insulin secretion, metabolome, microbiome, natural phenotypic variation, obesity, transcriptome, trimethylamine-N-oxide, anxiety disorder, anxiete, obésité, sécrétion d'insuline, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Science & Technology, Life Sciences & Biomedicine, Cell Biology, HUMAN GUT MICROBIOME, HIGH-FAT DIET, ENDOPLASMIC-RETICULUM STRESS, CONTAINING MONOOXYGENASE 3, UNFOLDED PROTEIN RESPONSE, INSULIN-RESISTANT MICE, L-CARNITINE, BACTERIAL METABOLITES, CHEMICAL CHAPERONES, Article, Biologie du développement, Development Biology, TMAO;anxiety;endoplasmic reticulum stress;impaired glucose tolerance;insulin secretion;metabolome;microbiome;natural phenotypic variation;obesity;transcriptome;trimethylamine-N-oxide, Biology (General), QH301-705.5, General Biochemistry, Genetics and Molecular Biology, Homeostasis, Internal medicine, medicine.medical_specialty, medicine, Trimethylamine N-oxide, chemistry.chemical_compound, chemistry, Population, education.field_of_study, education, Biology, Endocrinology, Genetic heterogeneity, medicine.disease, Lipogenesis
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