publication . Thesis

Ocular and systemic vascular dysfunction in neurodegenerative disease

Mroczkowska, Stephanie;
Open Access English
  • Country: United Kingdom
Abstract
The important role played by vascular factors in the pathogenesis of neurodegenerative disease has been increasingly realised over recent years. The nature and impact of ocular and systemic vascular dysfunction in the pathogenesis of comparable neurodegenerative diseases such as glaucoma and Alzheimer’s disease (AD) has however never been fully explored. The aim of this thesis was therefore to investigate the presence of macro- and micro-vascular alterations in both glaucoma and AD and to explore the relationships between these two chronic, slowly progressive neurodegenerative diseases. The principle sections and findings of this work were: 1. Is the eye a windo...
Subjects
Medical Subject Headings: genetic structureseye diseasessense organs
Related Organizations
157 references, page 1 of 11

614. Yoshitake T, Kiyohara Y, Kato I, et al. Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population. Neurology 1995;45:1161-1168. [OpenAIRE]

615. De la Torre JC. How do heart disease and stroke become risk factors for Alzheimer's disease? Neurological Research 2006;28:637-644.

616. Sparks DL, Martin TA, Gross DR, Hunsaker JC. Link between heart disease, cholesterol, and Alzheimer's disease: A review. Microscopy Research and Technique 2000;50:287-290.

617. de la Torre JC. The Vascular Hypothesis of Alzheimer's Disease: Bench to Bedside and Beyond. Neurodegenerative disease 2010;7:116-121.

618. Helzner E, J L, Scarmeas N, et al. Contribution of vascular risk factors to the progression in Alzheimer's disease. Arch Neurol 2009;66:343-348. [OpenAIRE]

619. Jeynes B, Provias J. The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease. Journal of Neuroscience Research 2011;89:22-28.

620. Marchesi VT. Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy. The FASEB Journal 2011;25:5-13.

621. Altman R, Rutledge JC. The vascular contribution to Alzheimer's disease. Clinical science 2010;119:407-421.

622. O'Brien JT, Eagger S, Syed GM, Sahakian BJ, Levy R. A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease. Journal of Neurology, Neurosurgery & Psychiatry 1992;55:1182-1187. [OpenAIRE]

623. Ruitenberg A, Heijer Td, Bakker SLM, et al. Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study. Annals of Neurology 2005;57:789-794. [OpenAIRE]

624. Johnson NA, Jahng G-H, Weiner MW, et al. Pattern of Cerebral Hypoperfusion in Alzheimer Disease and Mild Cognitive Impairment Measured with Arterial Spinlabeling MR Imaging: Initial Experience1. Radiology 2005;234:851-859. [OpenAIRE]

625. Pakrasi S, O'Brien JT. Emission tomography in dementia. Nuclear Medicine Communications 2005;26:189-196. [OpenAIRE]

626. Bateman GA, Levi CR, Schofield P, Wang Y, Lovett EC. Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer's disease. Journal of Clinical Neuroscience 2006;13:563-568.

627. Prohovnik I, Mayeux R, Sackeim HA, Smith G, Stern Y, Alderson PO. Cerebral perfusion as a diagnostic marker of early Alzheimer's disease. Neurology 1988;38:931. [OpenAIRE]

628. Bell R, Zlokovic B. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathologica 2009;118:103-113. [OpenAIRE]

157 references, page 1 of 11
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