publication . Article . Other literature type . 2017

The EU-AIMS Longitudinal European Autism Project (LEAP): Design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders

Loth, Eva; Charman, Tony; Mason, Luke; Tillmann, Julian; Jones, Emily JH; Wooldridge, Caroline; Ahmad, Jumana; Auyeung, Bonnie; Brogna, Claudia; Ambrosino, Sara; ...
Open Access English
  • Published: 23 Jun 2017
  • Publisher: HAL CCSD
Abstract
Abstract Background The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control dif...
Subjects
free text keywords: Department of Child and Adolescent Psychiatry, 610 Medicine & health, Biomarkers, Cognition, EEG, Eye-tracking, Genetics, MRI, Neuroimaging, Psychiatry, Psykiatri, /dk/atira/pure/subjectarea/asjc/1300/1312, /dk/atira/pure/subjectarea/asjc/2800/2806, /dk/atira/pure/subjectarea/asjc/1300/1309, /dk/atira/pure/subjectarea/asjc/2700/2738, eye tracking, Biomarkers, Cognition, EEG, Eye-tracking, Genetics, MRI, Neuroimaging, [SDV]Life Sciences [q-bio], psyc, [ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [ SDV.GEN ] Life Sciences [q-bio]/Genetics, [ SHS.PSY ] Humanities and Social Sciences/Psychology, BF, Research, Brain, Saliva, Hair, Humans, Magnetic Resonance Imaging, Longitudinal Studies, Individuality, Siblings, Phenotype, Patient Selection, Adult, Child, Female, Male, Eye Movement Measurements, Neurology. Diseases of the nervous system, RC346-429, Journal Article, Developmental Biology, Developmental Neuroscience, Molecular Biology, Psychiatry and Mental health, Psychology, Autism, medicine.disease, medicine, Neurocognitive, Precision medicine, Observational study, Developmental psychology, Autism spectrum disorder, Intellectual disability, Genetic heterogeneity, Cohort
Funded by
EC| EU-AIMS
Project
EU-AIMS
European Autism Interventions - A Multicentre Study for Developing New Medications
  • Funder: European Commission (EC)
  • Project Code: 115300
  • Funding stream: FP7 | SP1 | SP1-JTI
Communities
Neuroinformatics
HAL-Inserm
Article . 2017
Provider: HAL-Inserm
NARCIS
Article . 2017
Provider: NARCIS
HAL-CEA
Article . 2017
Provider: HAL-CEA
Hal-Diderot
Article . 2017
Provider: Hal-Diderot
117 references, page 1 of 8

1. Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders-Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ. 2012;61:1-19.

2. Kanner L. Autistic disturbances of affective contact. Nerv Child. 1943;2:217-50.

3. Asperger H. Die “Autistischen Psychopathen” im Kindesalter. Archiv fuer Psychiatrie und Nervenkrankheiten. 1944;117:76-136.

4. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (Fifth ed.). Arlington: American Psychiatric Publishing; 2013.

5. Charman T. Variability in neurodevelopmental disorders: evidence from autism. In: Riby D, Van Herwegen J, editors. Applied Research and Key Issues in Neurodevelopmental Disorders. Routledge Psychology Press; 2015. p. 117-40.

6. Charman T, Jones CR, Pickles A, Simonoff E, Baird G, Happe F. Defining the cognitive phenotype of autism. Brain Res. 2011;1380:10-21. [OpenAIRE]

7. Bourgeron T. From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci. 2015;16:551-63. [OpenAIRE]

8. Sahin M, Sur M. Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders. Science. 2015;350:921-9.

9. Geschwind DH. Advances in autism. Annu Rev Med. 2009;60:367-80. [OpenAIRE]

10. Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med. 2013;11:126. [OpenAIRE]

11. Button KS, Ioannidis JP, Mokrysz C, Nosek BA, Flint J, Robinson ES, Munafo MR. Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 2013;14:365-76.

12. Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2:e124.

13. Ioannidis JP. How to make more published research true. PLoS Med. 2014; 11:e1001747.

14. Murphy D, Spooren W. EU-AIMS: a boost to autism research. Nat Rev Drug Discov. 2012;11:815-6.

15. Loth E, Spooren W, Murphy DG, Consortium E-A. New treatment targets for autism spectrum disorders: EU-AIMS. Lancet Psychiatry. 2014;1:413-5.

117 references, page 1 of 8
Abstract
Abstract Background The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control dif...
Subjects
free text keywords: Department of Child and Adolescent Psychiatry, 610 Medicine & health, Biomarkers, Cognition, EEG, Eye-tracking, Genetics, MRI, Neuroimaging, Psychiatry, Psykiatri, /dk/atira/pure/subjectarea/asjc/1300/1312, /dk/atira/pure/subjectarea/asjc/2800/2806, /dk/atira/pure/subjectarea/asjc/1300/1309, /dk/atira/pure/subjectarea/asjc/2700/2738, eye tracking, Biomarkers, Cognition, EEG, Eye-tracking, Genetics, MRI, Neuroimaging, [SDV]Life Sciences [q-bio], psyc, [ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [ SDV.GEN ] Life Sciences [q-bio]/Genetics, [ SHS.PSY ] Humanities and Social Sciences/Psychology, BF, Research, Brain, Saliva, Hair, Humans, Magnetic Resonance Imaging, Longitudinal Studies, Individuality, Siblings, Phenotype, Patient Selection, Adult, Child, Female, Male, Eye Movement Measurements, Neurology. Diseases of the nervous system, RC346-429, Journal Article, Developmental Biology, Developmental Neuroscience, Molecular Biology, Psychiatry and Mental health, Psychology, Autism, medicine.disease, medicine, Neurocognitive, Precision medicine, Observational study, Developmental psychology, Autism spectrum disorder, Intellectual disability, Genetic heterogeneity, Cohort
Funded by
EC| EU-AIMS
Project
EU-AIMS
European Autism Interventions - A Multicentre Study for Developing New Medications
  • Funder: European Commission (EC)
  • Project Code: 115300
  • Funding stream: FP7 | SP1 | SP1-JTI
Communities
Neuroinformatics
HAL-Inserm
Article . 2017
Provider: HAL-Inserm
NARCIS
Article . 2017
Provider: NARCIS
HAL-CEA
Article . 2017
Provider: HAL-CEA
Hal-Diderot
Article . 2017
Provider: Hal-Diderot
117 references, page 1 of 8

1. Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders-Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ. 2012;61:1-19.

2. Kanner L. Autistic disturbances of affective contact. Nerv Child. 1943;2:217-50.

3. Asperger H. Die “Autistischen Psychopathen” im Kindesalter. Archiv fuer Psychiatrie und Nervenkrankheiten. 1944;117:76-136.

4. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (Fifth ed.). Arlington: American Psychiatric Publishing; 2013.

5. Charman T. Variability in neurodevelopmental disorders: evidence from autism. In: Riby D, Van Herwegen J, editors. Applied Research and Key Issues in Neurodevelopmental Disorders. Routledge Psychology Press; 2015. p. 117-40.

6. Charman T, Jones CR, Pickles A, Simonoff E, Baird G, Happe F. Defining the cognitive phenotype of autism. Brain Res. 2011;1380:10-21. [OpenAIRE]

7. Bourgeron T. From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat Rev Neurosci. 2015;16:551-63. [OpenAIRE]

8. Sahin M, Sur M. Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders. Science. 2015;350:921-9.

9. Geschwind DH. Advances in autism. Annu Rev Med. 2009;60:367-80. [OpenAIRE]

10. Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med. 2013;11:126. [OpenAIRE]

11. Button KS, Ioannidis JP, Mokrysz C, Nosek BA, Flint J, Robinson ES, Munafo MR. Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci. 2013;14:365-76.

12. Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2:e124.

13. Ioannidis JP. How to make more published research true. PLoS Med. 2014; 11:e1001747.

14. Murphy D, Spooren W. EU-AIMS: a boost to autism research. Nat Rev Drug Discov. 2012;11:815-6.

15. Loth E, Spooren W, Murphy DG, Consortium E-A. New treatment targets for autism spectrum disorders: EU-AIMS. Lancet Psychiatry. 2014;1:413-5.

117 references, page 1 of 8
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