Role of Mef2 in Drosophila muscle development

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Hancock, Daniel H.;
  • Subject: QR | QH301
    mesheuropmc: cardiovascular system | tissues | embryonic structures | musculoskeletal system | animal structures

Muscle differentiation is a complex process involving the transition from undifferentiated mesoderm to a final functional musculature. Mef2 is an essential positive regulator central to the co-ordination of this process. It targets a plethora of key genes both early and... View more
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    25 25 25 26 26 26 26 27 27 28 28 29 29 29 30 3.5.1 Co-expression full length Mef2 rescues the S tl7 phenotype associated with the Mef2 Dominant Negative 3.5.2 Ectopic expression o f a Mef2 target gene is lost when the Mef2 dominant negative is co-expressed with UAS Mef2 8.2.1 Design of GFP Reporter constructs 8.2.2 mesol8E C GFP pStinger Reporter expression 8.2.3 mesoJ8E D GFP pStinger Reporter expression 8.2.4 Site Directed Mutagenesis to the Mef2 site in the mesol8E C GFP reporter reveals mesol8E to be a direct target of Mef2

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