Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation

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Kim, J.-R.; Kim, J.-S.; Postlethwaite, I.; Heslop-Harrison, P.; Bates, D.G.;
  • Publisher: Society of Instrument and Control Engineers / IEEE Computer Society
  • Subject: QA

This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the model output and ex... View more
  • References (6)

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    [2] Prathyush P. Menon, Jongrae Kim, Declan G. Bates, and Ian Postlethwaite. Clearance of nonlinear flight control laws using hybrid evolutionary optimisation. IEEE Transactions on Evolutionary Computation, 10(6):689-699, December 2006.

    [3] Moise´s Santilla´n and Michael C. Mackey. Dynamic reguiation of the tryptophan operon: A modeling study and comparison with experimental data. Proceedings of the National Academy of Sciences, 98(4):1364-1369, February 2001.

    [4] Moise´s Santilla´n and Eduardo S. Zeron. Analytical study of the multiplicity of regulatory mechanisms in the tryptophan operon. Bulletin of Mathematical Biology, 68(2):343-359, February 2006.

    [5] Zhi-Long Xiu, Zeng-Yi Chang, and An-Ping Zeng. Nonlinear dynamics of regulation of bacterial trp operon: Model analysis of integrated effects of repression, feedback inhibition, and attenuation. Biotechnology Progress, 18(4):686-693, August 2002.

    [6] Charles Yanofsky and Virginia Horn. Role of regulatory features of the trp operon of Escherichia coli in mediating a response to a nutritional shift. Journal of Bacteriology, 176(20):6245-6254, October 1994.

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