Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+T cells in chronic infection

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Nitschke, Katja; Flecken, Tobias; Schmidt, Julia; Gostick, Emma; Marget, Matthias; Neumann-Haefelin, Christoph; Blum, Hubert E.; Price, David; Thimme, Robert; Diamond, M. S.;

Virus-specific CD8+ T cells are rarely detectable ex vivo by conventional methods during chronic hepatitis C virus (HCV) infection. In this study, however, we were able to detect and characterize HCV-specific CD8+ T cells in all chronically HCV genotype 1a-infected, HLA... View more
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