publication . Article . 2013

Metabolite-dependent regulation of gene expression in trypanosoma brucei

Kim, D.-H.; Barrett, M.P.;
Open Access English
  • Published: 01 Jun 2013
  • Publisher: Wiley
  • Country: India
Abstract
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic RNAs producing monocistronic RNAs whose translation may then depend upon information within their 3′ untranslated regions (3′UTRs). Various 3′UTR sequences involved in life-cycle stage-dependent differential gene expression have been described. Moreover, several RNA-binding proteins have been implicated in regulating expression of these transcripts through altering either their stability or their ability to intera...
Related Organizations
Funded by
WT| The Wellcome Trust Centre for Molecular Parasitology
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 085349
  • Funding stream: Immune System in Health and Disease
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35 references, page 1 of 3

Archer, S.K., Inchaustegui, D., Queiroz, R., and Clayton, C. (2011) The cell cycle regulated transcriptome of Trypanosoma brucei. PLoS ONE 6: e18425. [OpenAIRE]

Batey, R.T. (2011) Recognition of S-adenosylmethionine by riboswitches. Wiley Interdiscip Rev RNA 2: 299-311. [OpenAIRE]

Besteiro, S., Barrett, M., Rivière, L., and Bringaud, F. (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends Parasitol 21: 185-191. [OpenAIRE]

Birkholtz, L.M., Williams, M., Niemand, J., Louw, A.I., Persson, L., and Heby, O. (2011) Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities. Biochem J 438: 229-244.

Breaker, R.R. (2012) Riboswitches and the RNA world. Cold Spring Harb Perspect Biol 4: a003566.

Carter, N.S., Yates, P.A., Gessford, S.K., Galagan, S.R., Landfear, S.M., and Ullman, B. (2010) Adaptive responses to purine starvation in Leishmania donovani. Mol Microbiol 78: 92-107.

Clayton, C.E. (2002) Life without transcriptional control? From fly to man and back again. EMBO J 21: 1881-1888.

Coustou, V., Biran, M., Breton, M., Guegan, F., Rivière, L., Plazolles, N., et al. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. J Biol Chem 283: 16342-16354. [OpenAIRE]

De Gaudenzi, J.G., Noe, G., Campo, V.A., Frasch, A.C., and Cassola, A. (2011) Gene expression regulation in trypanosomatids. Essays Biochem 51: 31-46. [OpenAIRE]

Ebikeme, C., Hubert, J., Biran, M., Gouspillou, G., Morand, P., Plazolles, N., et al. (2010) Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism. J Biol Chem 285: 32312-32324. [OpenAIRE]

Fairlamb, A.H., Blackburn, P., Ulrich, P., Chait, B.T., and Cerami, A. (1985) Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. Science 227: 1485-1487. [OpenAIRE]

Hendriks, E.F., and Matthews, K.R. (2005) Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein. Mol Microbiol 57: 706-716.

Jacob, F., and Monod, J. (1961) Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol 3: 318-356. [OpenAIRE]

Jensen, B., Sivam, D., Kifer, C., Myler, P., and Parsons, M. (2009) Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei. BMC Genomics 10: 482. [OpenAIRE]

Kabani, S., Fenn, K., Ross, A., Ivens, A., Smith, T., Ghazal, P., and Matthews, K. (2009) Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei. BMC Genomics 10: 427. [OpenAIRE]

35 references, page 1 of 3
Related research
Abstract
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic RNAs producing monocistronic RNAs whose translation may then depend upon information within their 3′ untranslated regions (3′UTRs). Various 3′UTR sequences involved in life-cycle stage-dependent differential gene expression have been described. Moreover, several RNA-binding proteins have been implicated in regulating expression of these transcripts through altering either their stability or their ability to intera...
Related Organizations
Funded by
WT| The Wellcome Trust Centre for Molecular Parasitology
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 085349
  • Funding stream: Immune System in Health and Disease
Download from
35 references, page 1 of 3

Archer, S.K., Inchaustegui, D., Queiroz, R., and Clayton, C. (2011) The cell cycle regulated transcriptome of Trypanosoma brucei. PLoS ONE 6: e18425. [OpenAIRE]

Batey, R.T. (2011) Recognition of S-adenosylmethionine by riboswitches. Wiley Interdiscip Rev RNA 2: 299-311. [OpenAIRE]

Besteiro, S., Barrett, M., Rivière, L., and Bringaud, F. (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends Parasitol 21: 185-191. [OpenAIRE]

Birkholtz, L.M., Williams, M., Niemand, J., Louw, A.I., Persson, L., and Heby, O. (2011) Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities. Biochem J 438: 229-244.

Breaker, R.R. (2012) Riboswitches and the RNA world. Cold Spring Harb Perspect Biol 4: a003566.

Carter, N.S., Yates, P.A., Gessford, S.K., Galagan, S.R., Landfear, S.M., and Ullman, B. (2010) Adaptive responses to purine starvation in Leishmania donovani. Mol Microbiol 78: 92-107.

Clayton, C.E. (2002) Life without transcriptional control? From fly to man and back again. EMBO J 21: 1881-1888.

Coustou, V., Biran, M., Breton, M., Guegan, F., Rivière, L., Plazolles, N., et al. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. J Biol Chem 283: 16342-16354. [OpenAIRE]

De Gaudenzi, J.G., Noe, G., Campo, V.A., Frasch, A.C., and Cassola, A. (2011) Gene expression regulation in trypanosomatids. Essays Biochem 51: 31-46. [OpenAIRE]

Ebikeme, C., Hubert, J., Biran, M., Gouspillou, G., Morand, P., Plazolles, N., et al. (2010) Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism. J Biol Chem 285: 32312-32324. [OpenAIRE]

Fairlamb, A.H., Blackburn, P., Ulrich, P., Chait, B.T., and Cerami, A. (1985) Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. Science 227: 1485-1487. [OpenAIRE]

Hendriks, E.F., and Matthews, K.R. (2005) Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein. Mol Microbiol 57: 706-716.

Jacob, F., and Monod, J. (1961) Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol 3: 318-356. [OpenAIRE]

Jensen, B., Sivam, D., Kifer, C., Myler, P., and Parsons, M. (2009) Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei. BMC Genomics 10: 482. [OpenAIRE]

Kabani, S., Fenn, K., Ross, A., Ivens, A., Smith, T., Ghazal, P., and Matthews, K. (2009) Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei. BMC Genomics 10: 427. [OpenAIRE]

35 references, page 1 of 3
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