publication . Article . Other literature type . 2017

HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer

Mansour, Mohammed A.; Senga, Takeshi;
Open Access
  • Published: 01 Jul 2017 Journal: The International Journal of Biochemistry & Cell Biology, volume 88, pages 1-13 (issn: 1357-2725, Copyright policy)
  • Publisher: Elsevier BV
  • Country: India
Abstract
Homeobox (HOX) genes are conserved transcription factors which determine the anterior-posterior body axis patterning. HOXD8 is a member of HOX genes deregulated in several tumors such as lung carcinoma, neuroblastoma, glioma and colorectal cancer (CRC) in a context-dependent manner. In CRC, HOXD8 is downregulated in cancer tissues and metastatic foci as compared to normal tissues. Whether HOXD8 acts as a tumor suppressor of malignant progression and metastasis is still unclear. Also, the underlying mechanism of its function including the downstream targets is totally unknown. Here, we clarified the lower expression of HOXD8 in clinical colorectal cancer vs. norm...
Subjects
free text keywords: Mouse model of colorectal and intestinal cancer, Metastasis, medicine.disease, medicine, Hox gene, Cancer research, Colorectal cancer, Transcription factor, Neuroblastoma, Deleted in Colorectal Cancer, Cancer, Biology
Related Organizations

(1) Kanai M, Hamada J, Takada M, et al. Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas. Oncol Rep. 2010;23(3):843-51.

(2) Levine M, Hoey T. Homeobox proteins as sequence-specific transcription factors. Cell. 1988;55(4):537-40.

Related research
Abstract
Homeobox (HOX) genes are conserved transcription factors which determine the anterior-posterior body axis patterning. HOXD8 is a member of HOX genes deregulated in several tumors such as lung carcinoma, neuroblastoma, glioma and colorectal cancer (CRC) in a context-dependent manner. In CRC, HOXD8 is downregulated in cancer tissues and metastatic foci as compared to normal tissues. Whether HOXD8 acts as a tumor suppressor of malignant progression and metastasis is still unclear. Also, the underlying mechanism of its function including the downstream targets is totally unknown. Here, we clarified the lower expression of HOXD8 in clinical colorectal cancer vs. norm...
Subjects
free text keywords: Mouse model of colorectal and intestinal cancer, Metastasis, medicine.disease, medicine, Hox gene, Cancer research, Colorectal cancer, Transcription factor, Neuroblastoma, Deleted in Colorectal Cancer, Cancer, Biology
Related Organizations

(1) Kanai M, Hamada J, Takada M, et al. Aberrant expressions of HOX genes in colorectal and hepatocellular carcinomas. Oncol Rep. 2010;23(3):843-51.

(2) Levine M, Hoey T. Homeobox proteins as sequence-specific transcription factors. Cell. 1988;55(4):537-40.

Related research
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