publication . Article . 2015

Death Dilemma and Organism Recovery in Ecotoxicology

Ashauer, Roman; O'Connor, Isabel; Hintermeister, Anita; Escher, Beate I.;
Open Access
  • Published: 29 Jul 2015 Journal: Environmental Science & Technology, volume 49, pages 10,136-10,146 (issn: 0013-936X, eissn: 1520-5851, Copyright policy)
  • Publisher: American Chemical Society (ACS)
  • Country: United Kingdom
Abstract
Why do some individuals survive after exposure to chemicals while others die? Either, the tolerance threshold is distributed among the individuals in a population, and its exceedance leads to certain death, or all individuals share the same threshold above which death occurs stochastically. The previously published General Unified Threshold model of Survival (GUTS) established a mathematical relationship between the two assumptions. According to this model stochastic death would result in systematically faster compensation and damage repair mechanisms than individual tolerance. Thus, we face a circular conclusion dilemma because inference about the death mechani...
Subjects
free text keywords: General Chemistry, Environmental Chemistry, Econometrics, Biology, Ecotoxicology, Mathematical relationship, Environmental engineering, Dilemma, Threshold model, Organism, Population, education.field_of_study, education, Inference, Survival analysis, Ecology, 1600, 2304
100 references, page 1 of 7

(1) Berkson, J. Why I prefer logits to probits. Biometrics 1951, 7 (4), 327−339.

(2) Newman, M. C.; McCloskey, J. T. The individual tolerance concept is not the sole explanation for the probit dose-effect model.

Environ. Toxicol. Chem. 2000, 19 (2), 520−526.

(3) Jager, T.; Albert, C.; Preuss, T. G.; Ashauer, R. General Unified Threshold Model of Survival - a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology. Environ. Sci. Technol. 2011, 45 (7), 2529−2540.

(4) Sprague, J. B. Measurement of pollutant toxicity to fish.I. Bioassay methods for acute toxicity. Water Res. 1969, 3 (11), 793−821.

(5) Ashauer, R.; Boxall, A. B. A.; Brown, C. D. Simulating toxicity of carbaryl to Gammarus pulex after sequential pulsed exposure. Environ.

Sci. Technol. 2007, 41 (15), 5528−5534.

(6) Jager, T.; Kooijman, S. A. L. M. A biology-based approach for quantitative structure-activity relationships (QSARs) in ecotoxicity.

Ecotoxicology 2009, 18 (2), 187−196.

(7) Ashauer, R.; Hintermeister, A.; O'Connor, I.; Elumelu, M.; Hollender, J.; Escher, B. I. Significance of Xenobiotic Metabolism for Bioaccumulation Kinetics of Organic Chemicals in Gammarus pulex.

Environ. Sci. Technol. 2012, 46 (6), 3498−3508.

(8) Nyman, A.-M.; Schirmer, K.; Ashauer, R. Toxicokinetictoxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power. Ecotoxicology 2012, 21 (7), 1828− 1840. [OpenAIRE]

(9) Ashauer, R.; Hintermeister, A.; Caravatti, I.; Kretschmann, A.; Escher, B. I. Toxicokinetic-toxicodynamic modeling explains carry-over toxicity from exposure to diazinon by slow organism recovery. Environ.

Sci. Technol. 2010, 44 (10), 3963−3971.

(10) Naylor, C.; Maltby, L.; Calow, P. Scope for growth in Gammarus pulex, a fresh-water benthic detritivore. Hydrobiologia 1989, 188−189 (1), 517−523. [OpenAIRE]

100 references, page 1 of 7
Related research
Abstract
Why do some individuals survive after exposure to chemicals while others die? Either, the tolerance threshold is distributed among the individuals in a population, and its exceedance leads to certain death, or all individuals share the same threshold above which death occurs stochastically. The previously published General Unified Threshold model of Survival (GUTS) established a mathematical relationship between the two assumptions. According to this model stochastic death would result in systematically faster compensation and damage repair mechanisms than individual tolerance. Thus, we face a circular conclusion dilemma because inference about the death mechani...
Subjects
free text keywords: General Chemistry, Environmental Chemistry, Econometrics, Biology, Ecotoxicology, Mathematical relationship, Environmental engineering, Dilemma, Threshold model, Organism, Population, education.field_of_study, education, Inference, Survival analysis, Ecology, 1600, 2304
100 references, page 1 of 7

(1) Berkson, J. Why I prefer logits to probits. Biometrics 1951, 7 (4), 327−339.

(2) Newman, M. C.; McCloskey, J. T. The individual tolerance concept is not the sole explanation for the probit dose-effect model.

Environ. Toxicol. Chem. 2000, 19 (2), 520−526.

(3) Jager, T.; Albert, C.; Preuss, T. G.; Ashauer, R. General Unified Threshold Model of Survival - a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology. Environ. Sci. Technol. 2011, 45 (7), 2529−2540.

(4) Sprague, J. B. Measurement of pollutant toxicity to fish.I. Bioassay methods for acute toxicity. Water Res. 1969, 3 (11), 793−821.

(5) Ashauer, R.; Boxall, A. B. A.; Brown, C. D. Simulating toxicity of carbaryl to Gammarus pulex after sequential pulsed exposure. Environ.

Sci. Technol. 2007, 41 (15), 5528−5534.

(6) Jager, T.; Kooijman, S. A. L. M. A biology-based approach for quantitative structure-activity relationships (QSARs) in ecotoxicity.

Ecotoxicology 2009, 18 (2), 187−196.

(7) Ashauer, R.; Hintermeister, A.; O'Connor, I.; Elumelu, M.; Hollender, J.; Escher, B. I. Significance of Xenobiotic Metabolism for Bioaccumulation Kinetics of Organic Chemicals in Gammarus pulex.

Environ. Sci. Technol. 2012, 46 (6), 3498−3508.

(8) Nyman, A.-M.; Schirmer, K.; Ashauer, R. Toxicokinetictoxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power. Ecotoxicology 2012, 21 (7), 1828− 1840. [OpenAIRE]

(9) Ashauer, R.; Hintermeister, A.; Caravatti, I.; Kretschmann, A.; Escher, B. I. Toxicokinetic-toxicodynamic modeling explains carry-over toxicity from exposure to diazinon by slow organism recovery. Environ.

Sci. Technol. 2010, 44 (10), 3963−3971.

(10) Naylor, C.; Maltby, L.; Calow, P. Scope for growth in Gammarus pulex, a fresh-water benthic detritivore. Hydrobiologia 1989, 188−189 (1), 517−523. [OpenAIRE]

100 references, page 1 of 7
Related research
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