publication . Thesis . 2018

Roles of the Histone Chaperone FACT in Drosophila Gene Regulation and Chromatin Architecture

Tettey, Theophilus;
Open Access English
  • Published: 14 Mar 2018
Abstract
The highly conserved histone chaperone FACT (Facilitates Chromatin Transcription) is thought to contribute to the disassembly and reassembly of nucleosomes in the wake of RNA polymerase II passage through chromatin. In yeast, mutation of FACT subunits leads to decreased nucleosome occupancy at the promoters and transcribed regions of genes. In addition, genetic experiments suggest that yeast FACT plays a critical role in restricting initiation of transcription to promoters, ensuring that only appropriate mRNAs are synthesized.\ud \ud However, FACT’s roles in chromatin biology and transcriptional regulation in higher eukaryotes are not well understood. Using Dros...
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